NCT07379385

Brief Summary

The progressive loss of strength and muscle mass is a natural aging process, with direct implications for functional capacity. Resistance training (RT) is considered the main intervention to counteract this decline. Although the RT guidelines are well established, the ideal weekly set volume to maximize strength and hypertrophy gains in older adults remains unknown. The purpose of this study is to investigate the effects of different volumes of weekly sets of RT on muscle strength and hypertrophy in older adults

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
57

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2026

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

January 7, 2026

Completed
23 days until next milestone

First Posted

Study publicly available on registry

January 30, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 6, 2026

Completed
4 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 10, 2026

Completed
Last Updated

January 30, 2026

Status Verified

January 1, 2026

Enrollment Period

3 months

First QC Date

January 7, 2026

Last Update Submit

January 26, 2026

Conditions

Muscle PerformanceResistance Training

Keywords

Resistance exerciseWeekly set volumeTraining volumeMuscle hypertrophyMuscle strengthAging

Outcome Measures

Primary Outcomes (3)

  • Maximum dynamic strength (1RM)

    The one-repetition maximum test will be performed on a bilateral leg extension machine. Briefly, participants will undergo 3 test attempts, interspersed with 5-minute intervals. Loads of 10-15% will be added after each attempt in order to reach the 1RM load within the 3 trials. Participants will be verbally encouraged during each attempt.

    baseline and after 10 weeks of intervention

  • Maximum voluntary isometric contraction (MVIC)

    The MVIC test for the leg extension exercise (bilateral) will be performed using an isometric dynamometer (CEFISE Biotechnology, São Carlos, Brazil). Briefly, participants will perform three MVICs at 120º of knee flexion (180º = full extension) lasting 5 s, interspersed with 5 s of rest. Participants will be instructed and verbally encouraged to exert maximum force during all attempts. The highest value obtained for peak and mean torque of the three MVICs will be used for the analysis.

    baseline and after 10 weeks of intervention

  • Muscle hypertrophy (thickness)

    Muscle hypertrophy (thickness) of the quadriceps and rectus femoris muscles will be assessed using ultrasound images obtained at 3 anatomical points (30, 50, and 60% of the distance between the greater trochanter of the femur and the knee joint line). Muscle thickness will be analyzed using the image analysis program (ImageJ®).

    baseline and after 10 weeks of intervention

Secondary Outcomes (2)

  • Rating of perceive exterion (RPE)

    Immediately after completion of each set of exercise

  • Affective responses (pleasure and displeasure)

    Immediately after each exercise during training sessions

Study Arms (3)

Low Volume (LV)

EXPERIMENTAL

Participants will be performed 6 sets/week

Other: Low volume (LV)

Moderate Volume (MV)

EXPERIMENTAL

Participants will be performed 18 sets/week

Other: Moderate Volume (MV)

High Volume (HV)

EXPERIMENTAL

Participants will be performed 30 sets/week

Other: High Volume (HV)

Interventions

Low volume (LV)OTHER

Participants will be performed 6 sets/week during 10 weeks

Low Volume (LV)
Moderate Volume (MV)OTHER

Participants will be performed 18 sets/week during 10 weeks

Moderate Volume (MV)
High Volume (HV)OTHER

Participants will be performed 30 sets/week during 10 weeks

High Volume (HV)

Eligibility Criteria

Age65 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Age between 65 and 80 years

You may not qualify if:

  • not having used any medication or substance that affects or improves muscle function for at least 3 months prior to the study,
  • having any physical or physiological limitation that may affect the ability to perform the tests and physical training,
  • not being able to understand the informed consent form and study procedures.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northern University of Paraná

Londrina, Paraná, 86047-622, Brazil

Location

Related Publications (1)

  • Robertson RJ, Goss FL, Rutkowski J, Lenz B, Dixon C, Timmer J, Frazee K, Dube J, Andreacci J. Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med Sci Sports Exerc. 2003 Feb;35(2):333-41. doi: 10.1249/01.MSS.0000048831.15016.2A.

    PMID: 12569225RESULT

MeSH Terms

Interventions

Hospitals, Low-VolumeHospitals, High-Volume

Intervention Hierarchy (Ancestors)

HospitalsHealth FacilitiesHealth Care Facilities Workforce and Services

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 7, 2026

First Posted

January 30, 2026

Study Start

January 1, 2026

Primary Completion

April 6, 2026

Study Completion

April 10, 2026

Last Updated

January 30, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

BR(1)