The Effect of Nutritional Status on Postoperative Mortality and Morbidity in the Geriatric Population Undergoing Gastrointestinal Surgery

NCT07374055 | Active Not Recruiting

• 1 other identifier: KARTALANESTEZİ088
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to compare the sensitivity and specificity of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment Scale-Short Form (mNA-SF) and Systemic Immune-Inflammatory Index (SII) values calculated in the preoperative evaluation in patients over 65 years of age who underwent gastrointestinal surgery, in predicting morbidity and mortality in the postoperative period.

Conditions

Nutrition Assessment; Geriatric Anesthesia

Keywords

Geriatric; Nutritional; Mortality; Gastrointestinal surgery

Outcome Measures

Primary Outcomes (3)

• Systemic Immune-Inflammation Index (SII)

  Calculated as (Platelets x Neutrophils) / Lymphocytes from preoperative blood samples.The unit of measure is cells per microliter.

  Preoperative (Baseline)

• Geriatric Nutritional Risk Index (GNRI) as a predictor of postoperative complications

  GNRI will be calculated using serum albumin and body weight. Scores will be used to categorize patients' nutritional risk.Units on a scale of 0 to 120, where lower scores indicate higher nutritional risk.

  Preoperative (Baseline)

• Mini Nutritional Assessment-Short Form (mNA-SF) score

  A 6-question survey to screen for malnutrition.Measured on a scale of 0 to 14 points, where 0-7 indicates malnourishment.

  Preoperative (Baseline)

Secondary Outcomes (4)

• Postoperative Morbidity

  Up to 30 days post-surgery

• Incidence of Delirium

  Preoperative to discharge

• Length of Hospital and ICU Stay

  Total duration of hospitalization

• Postoperative Mortality Rate

  30, 60, and 90 days post-surgery

Study Arms (1)

Geriatric Gastrointestinal Surgery Patients.

This group consists of 200 geriatric patients aged 65 and older who are scheduled to undergo gastrointestinal surgery. Participants are within the ASA 3-4 risk groups and must have a Mini-Mental State Examination (MMSE) score of 21 or higher to be included.

Other: Preoperative Risk Scoring; Other: Postoperative Morbidite and Mortality Monitoring; Other: Delirium Assessment Protocol

Interventions

Preoperative Risk Scoring OTHER

Patients will be evaluated preoperatively using three distinct scoring systems: the Geriatric Nutritional Risk Index (GNRI), the Mini Nutritional Assessment-Short Form (mNA-SF), and the Systemic Immune-Inflammation Index (SII). These scores are calculated based on serum albumin levels, body weight, a 6-question survey, and laboratory values (platelets, neutrophils, and lymphocytes).

Geriatric Gastrointestinal Surgery Patients.

Delirium Assessment Protocol OTHER

Patients will be monitored for delirium preoperatively, on the first postoperative day, and before discharge using the Confusion Assessment Method (CAM/CAM-ICU) and the Richmond Agitation-Sedation Scale (RASS).

Geriatric Gastrointestinal Surgery Patients.

Postoperative Morbidite and Mortality Monitoring OTHER

Systematic tracking of postoperative outcomes including hospital and ICU stay duration, pulmonary complications (e.g., pneumonia, embolism), extrapulmonary complications (e.g., surgical site infection, organ failure, delirium), and mortality rates at 30, 60, and 90 days.

Geriatric Gastrointestinal Surgery Patients.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Geriatric patients scheduled for gastrointestinal surgery at a single-center tertiary care urban hospital (SBÜ Kartal Dr. Lütfi Kırdar City Hospital).".

You may qualify if:

• Patients scheduled to undergo gastrointestinal surgery.
• Age 65 years and older.
• ASA (American Society of Anesthesiologists) physical status class 3 or 4.
• Mini-Mental State Examination (MMSE) score of 21 or higher

You may not qualify if:

• Patients who do not consent to participate in the study.
• Patients with acute infection during the preoperative period.
• Patients who received albumin replacement in the preoperative period.
• Patients with a Mini-Mental State Examination (MMSE) score below 21.

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

Kartal Dr. Lutfi Kirdar City Hospital

Istanbul, Kartal, 34890, Turkey (Türkiye)

Location

Study Officials

• Minel N KUTUPOGLU SEZER, MD

  University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Doctor

Study Record Dates

• First Submitted: January 20, 2026
• First Posted: January 28, 2026
• Study Start: February 1, 2025
• Primary Completion: February 1, 2025
• Study Completion (Estimated): May 30, 2026
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Beginning 6 months and ending 36 months following article publication.
• Access Criteria: Researchers who provide a methodologically sound proposal to achieve aims in the approved proposal.

Locations

TU (1)