Effect of Initiation of Veno-venous ECMO on Urine Output and Acute Kidney Injury

NCT07368868 | Completed DMC

• 1 other identifier: ONZ-2025-0269
• Study Type: observational
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

With this study, the investigators want to find out whether the use of a "lung machine" (extracorporeal membrane oxygenation (ECMO)) togethet with giving the lungs "rest" (by minimizing ventilary support) in people with severe pneumonia has an effect on how well the kidneys work. The investigators will use information that was already collected while patients were staying in the intensive care unit. Patients do not need to do anything additional or undergo any additional procedures for this study.

Conditions

ECMO; ARDS (Acute Respiratory Distress Syndrome); Acute Kidney Injury

Keywords

ECMO; acute kidney injury; ARDS

Outcome Measures

Primary Outcomes (1)

• Difference in urine output (staged by KDIGO criteria) 6h before and after start veno-venous ECMO and ultraprotective ventilation

  The difference in urine output will be investigated before and after start of veno-venous ECMO together with the initiation of ultraprotective ventilation. To compare the difference in urine output a timeframe of 6 hours before ECMO wil be compared to a timeframe six hours after ECMO initiation. The 6 hour timeframe was choosen because this is the duration of the AKI KDIGO stage 1 urine output criterium.

  6 hours

Secondary Outcomes (3)

• Difference in urine output (staged by KDIGO criteria) 12h before and after start veno-venous ECMO and ultraprotective ventilation.

  12 hours

• Difference in urine output (staged by KDIGO criteria) 24h before and after start veno-venous ECMO and ultraprotective ventilation.

  24 hours

• Difference in serum creatinine (staged by KDIGO criteria) 24h before and after start veno-venous ECMO and ultraprotective ventilation.

  24 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted on the ICU of Ghent Univesity Hospital with acute respiratory distress who received support by veno-venous ECMO between 1 January 2019 and 31 December 2023

You may qualify if:

• Age 18 years or older
• Admission to the Intensive Care Unit (ICU) of Ghent University Hospital
• Treatment with veno-venous extracorporeal membrane oxygenation (VV- ECMO)
• ICU admission between 1 January 2019 and 31 December 2023

You may not qualify if:

• Receipt of renal replacement therapy (RRT) prior to ICU admission
• Patients already receiving VV-ECMO at the time of admission to the ICU of Ghent University Hospital (i.e., patients referred from another hospital on VV-ECMO)
• Patients who received VV-ECMO immediately upon admission to the ICU of Ghent University Hospital

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent university hospital

Ghent, 9000, Belgium

Location

MeSH Terms

Conditions

Acute Lung Injury; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2026
• First Posted: January 27, 2026
• Study Start: December 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)