Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction

NCT07368777 | Recruiting

• 1 other identifier: 001
• Study Type: interventional
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.

Conditions

Adiposity; Overweight; Overweight and Obesity

Keywords

genotype-based nutrition; dietary counseling; weight loss; nutrigenetics

Outcome Measures

Primary Outcomes (1)

• Change in Fat Mass (%)

  Change in whole-body fat mass percentage from baseline to end of the intervention

  baseline to end of intervention (12 months)

Secondary Outcomes (2)

• Change in Body Weight

  baseline to end of intervention (12 months)

• Change in Lipid Profile

  baseline to end of intervention (12 months)

Study Arms (2)

Genotype-Based Dietary Counseling

EXPERIMENTAL

Participants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period.

Behavioral: Genotype-Based Dietary Counseling

Standard Dietary Counseling

ACTIVE COMPARATOR

Participants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information.

Behavioral: Standard Dietary Counseling

Interventions

Genotype-Based Dietary Counseling BEHAVIORAL

This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period.

Also known as: Nutrigenetic dietary counseling

Genotype-Based Dietary Counseling

Standard Dietary Counseling BEHAVIORAL

This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.

Also known as: General dietary recommendations

Standard Dietary Counseling

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged ≥18 years
• Body mass index (BMI) ≥25 kg/m²
• Greek-speaking (able to read and understand Greek and provide informed consent)
• Willing and able to participate in dietary counseling and study assessments for the duration of the study

You may not qualify if:

• Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
• Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
• Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
• Pregnancy or lactation
• Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders

Sponsors & Collaborators

• Metropolitan College: lead

Study Sites (1)

Dietetics Department, School of Health Sciences, Metropolitan College

Marousi, 151 25, Greece

RECRUITING

MeSH Terms

Conditions

Overweight; Obesity; Weight Loss

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes

Study Officials

• Angeliki Kapellou, PhD

  Dietetics Department, School of Health Sciences, Metropolitan College

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Angeliki Kapellou, PhD

CONTACT

+30 6938406218; akapellou@mitropolitiko.edu.gr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 20, 2026
• First Posted: January 27, 2026
• Study Start: December 15, 2025
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: January 28, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)