Evaluate the Efficacy of Faricimab in Patients With Neovascular Age-related Macular Degeneration

NCT07367282 | Not Yet Recruiting Phase 4

• 1 other identifier: AMD_ML46106
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

If the subject who has nAMD voluntarily agrees to participate in this clinical study by signing the informed consent form, screening assessments will be conducted within 4 weeks prior to the first dose of the investigational drug. During the screening visit, the eligibility of the subject will be assessed and one study eye will be selected. If both eyes are eligible, the eye with the worst best-corrected visual acuity (BCVA) at screening will be chosen. However, if the investigator determines that the other eye requires more urgent treatment for clinical reasons, that eye may be selected as the study eye. After screening assessments and evaluation based on inclusion/exclusion criteria, eligible subjects will be enrolled. Vabysmo® 6 mg (0.05 mL) will be administered via intravitreal injection every 4 weeks (monthly) for a total of 4 doses during the initial loading period. After the loading dose, patients will undergo disease activity assessment based on imaging and visual acuity (VA) outcomes followed by the IP administration at Week 20. The treatment interval will be determined based on disease activity assessed at Week 20, depending on the results, the subsequent administration may be scheduled at Week 28 or Week 32, at the investigator's discretion. Thereafter, the dosing interval may be further adjusted in 4-week increments, either extended or shortened, according to imaging and visual outcomes. Throughout the clinical study, patients will need to visit the study site at least 10 times, including the screening visit. The number of intravitreal injections administered will be 4 doses during the initial loading period and up to 5 doses during the treat-and-extend (T\&E) period (Weeks 20, 28, 36, 44, 52). Thus, the total number of injections during the study will range from a minimum of 7 to a maximum of 9 injections. If the non-study eye also has nAMD, treatment with a locally approved therapy may be administered outside the scope of this study.

Conditions

Macular Degeneration

Keywords

Neovascular Age-related Macular Degeneration

Outcome Measures

Primary Outcomes (1)

• ANG-2 level in aqueous humour (AH)

  Measurement of ANG-2 levels in aqueous humor (AH) and the change from baseline to week 20

  at Week 20 from baseline

Secondary Outcomes (14)

• Endothelial ANG-2 level in aqueous humour (AH)

  At weeks 4, 12, 20 and 52 from baseline

• BCVA measurement

  At weeks 20 and 52 from baseline

• Subfoveal choroidal thickness

  At weeks 20 and 52 from baseline

• Central subfield thickness (CST)

  At weeks 20 and 52 from baseline

• Intraretinal microaneurysms and vessel density of the deep capillary plexus

  At weeks 20 and 52 from baseline

Other Outcomes (2)

• AH biomarkers and imaging biomarkers

  From baseline to Week 52(EOS)

• AH biomarkers and the maximum treatment interval

  From baseline to Week 52(EOS)

Study Arms (1)

Faricimab

EXPERIMENTAL

Faricimab injection

Drug: Faricimab Injection [Vabysmo]

Interventions

Faricimab Injection [Vabysmo] DRUG

Faricimab Injection 6mg 0.05 cc

Faricimab

Eligibility Criteria

• Age: 50 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals who voluntarily agree to participate in this clinical study and provide written informed consent
• Male or female adults aged 50 years or older at the time of consent
• Individuals who, in the opinion of the investigator, are capable of complying with the requirements of the study protocol
• Ocular Conditions
• Individuals with a BCVA equivalent of ETDRS 24 letters or more, as measured at the time of screening.
• Confirmed diagnosis, by the investigator, of active nAMD based on sufficiently clear ocular media and adequate pupillary dilation allowing acquisition of good quality retinal images for confirmation.
• Treatment naïve patients
• For PCV patients, presence of active polypoidal lesions in the macula as shown by Indocyanine green angiography (ICGA) AND presence of serosanguinous maculopathy
• For PCV patients, greatest liner dimension (GLD) of the total lesion area \<5400 μm as delineated by ICGA.

You may not qualify if:

• Any major illness or major surgical procedure within 1 month before screening.
• Any condition that, in the opinion of the investigator, constitutes a contraindication to the use of faricimab, may affect interpretation of study results, or places the participant at high risk for treatment-related complications, based on medical history, non-diabetic metabolic abnormalities, physical examination findings, or past/current clinical laboratory results.
• History of active cancer within 12 months prior to screening, except for adequately treated carcinoma in situ of the cervix, non-melanoma skin cancer, or prostate cancer with a Gleason score ≤6 (Grade Group 1) and stable PSA levels for \>12 months.
• Uncontrolled blood pressure, defined as systolic \>180 mmHg and/or diastolic \>100 mmHg while at rest at baseline. A repeat reading within the screening window may be taken to confirm eligibility.
• Immune system abnormalities that may affect inflammatory biomarkers in aqueous humor (AH).
• History of severe allergic or anaphylactic reaction to biologic agents, or known hypersensitivity to any component of the faricimab injection, study-related procedures (including fluorescein and indocyanine green dyes), dilating drops, or any anesthetic/antimicrobial eye drops used during the study.
• Systemic treatment for suspected or active systemic infection at screening. Ongoing prophylactic antibiotic use may be acceptable at the investigator's discretion.
• Use of systemic medications known to have toxic effects on the lens, retina, or optic nerve within 6 months prior to screening or within 5 drug half-lives (whichever is longer), or expected future use of such medications.
• Receipt of systemic immunomodulatory therapy or immunosuppressive agents within 6 months prior to screening or within 5 drug half-lives (whichever is longer).
• Participation in another clinical study involving an investigational drug, investigational device, or other medical research within 3 months prior to screening, or concurrent participation in such a study.
• Pregnant or breastfeeding women.
• Women of childbearing potential planning to become pregnant during the study or within 3 months after the last dose of study treatment, or unwilling to use highly effective contraception methods\* throughout the study period and for 3 months following the last dose.
• Ocular Conditions
• Any ocular condition in the study eye that may interfere with the assessment of visual acuity, safety evaluation, or fundus imaging (e.g., advanced cataract).
• Any current ocular disease in the study eye that, in the opinion of the investigator, increases the procedural risk of intravitreal injection beyond standard expectations or may interfere with injection, efficacy, or safety evaluations.

Sponsors & Collaborators

• Junyeop Lee: lead

Study Sites (1)

Asan Medical Center

Seoul, South Korea

Location

MeSH Terms

Conditions

Macular Degeneration

Interventions

faricimab

Condition Hierarchy (Ancestors)

Retinal Degeneration; Retinal Diseases; Eye Diseases

Study Officials

• Junyeop Lee, PhD

  Asan Medical Center

  STUDY DIRECTOR

Central Study Contacts

Junyeop Lee, PhD

CONTACT

82-2-3010-3975; j.lee.amc@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 18, 2026
• First Posted: January 26, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): April 30, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)