A Study on the Efficacy of the Metaverse Lifestyle Health Education Model Based on the Transtheoretical Model for Improving Quality of Life and Modifying Lifestyle in Colorectal Cancer Survivors

NCT07362823 | Not Yet Recruiting

• 1 other identifier: XDYX202510K58
• Study Type: interventional
• Target: 174
• Locations: 0 countries
• Sites: N/A

Brief Summary

Colorectal cancer is a globally prevalent malignant tumor. Postoperative patients often face physical discomfort, psychological stress, and lack of healthy lifestyles. However, traditional health education models have limitations such as insufficient targeting and poor interactivity, making it difficult to meet their needs for full-cycle health management. This study is a multicenter randomized controlled trial, which plans to enroll 174 patients aged 18 years and above who have undergone radical resection for colorectal cancer, and randomly divide them into an experimental group and a control group at a ratio of 1:1. The experimental group will receive Transtheoretical Model (TTM)-based metaverse lifestyle health education (including phased course learning, metaverse immersive interaction, and WeChat group check-in supervision) with an intervention cycle of 1 months and follow-up until 3 months after the intervention; the control group will only receive routine paper-based education and outpatient follow-up. The study aims to verify the improvement effect of this metaverse intervention model on the quality of life and healthy lifestyle of colorectal cancer survivors, and explore its role in improving patients' self-efficacy, so as to provide empirical evidence for optimizing long-term health management programs for cancer survivors.

Conditions

Cancer Survivors; Colorectal Neoplasms

Keywords

Colorectal Neoplasms; Cancer Survivors; Transtheoretical Model (TTM); Metaverse; Lifestyle Intervention; Health Education; Quality of Life; Self-Efficacy; Health Behavior; Multicenter Randomized Controlled Trial

Outcome Measures

Primary Outcomes (2)

• Change in Health-Related Quality of Life Assessed by the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) Scale

  The FACT-C scale, a colorectal cancer-specific validated instrument, comprises 36 items across 5 domains (physical, social/family, emotional, functional well-being, and colorectal cancer-specific subscale). Scores are standardized to a 0-100 range, with higher scores indicating better quality of life. The outcome measures the change in standardized scores from baseline to 1 mouth and 3 months post-intervention.

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

• Improvement in Health-Promoting Behaviors Assessed by the Health-Promoting Lifestyle Profile II (HPLP II) Scale

  The HPLP II scale includes 52 items across 6 domains (self-actualization, health responsibility, physical activity, nutrition, interpersonal support, stress management). Scores range from 52 to 208, with higher scores reflecting more consistent health-promoting behaviors. The outcome measures the change in total scores from baseline to 1 month and 3 months post-intervention.

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

Secondary Outcomes (8)

• Change in Self-Efficacy Assessed by the Strategies Used by People to Promote Health (SUPPH) Scale

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

• Progression of Health Behavior Change Stages Assessed by the Transtheoretical Model (TTM) Stage Scale

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

• Change in BMI

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

• Change in CEA

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

• Change in Blood Glucose

  Baseline (T0), 1 month after intervention (T1), 3 months after intervention (T2)

Study Arms (2)

TTM-Based Metaverse Lifestyle Health Education Arm

EXPERIMENTAL

Administer TTM-phased lifestyle health education via metaverse platform (including health courses, immersive interactions, peer communities) and WeChat group check-in/medical Q\&A. Assess indicators at baseline, 1-month, 3-month post-intervention.

Behavioral: TTM-Based Metaverse Lifestyle Health Education

Routine Colorectal Cancer Postoperative Health Education Arm

NO INTERVENTION

Provide paper-based postoperative rehabilitation manual and verbal lifestyle guidance; conduct routine telephone/outpatient follow-up per hospital protocol. Assess indicators at the same time points as the intervention arm.

Interventions

TTM-Based Metaverse Lifestyle Health Education BEHAVIORAL

A three-month, stage-stratified behavioral intervention targeting colorectal cancer postoperative survivors, developed in alignment with the five stages of the Transtheoretical Model (TTM): pre-contemplation, contemplation, preparation, action, and maintenance. The intervention encompasses lifestyle modification modules (encompassing dietary guidance, physical activity protocols, and stress management) delivered via a metaverse platform-including didactic materials, immersive interactive modules, health behavior challenges, and peer support communities (20-30 minutes daily). It is supplemented by daily check-in prompts via WeChat groups and real-time clinical consultation from the research team. This intervention is designed to facilitate the adoption of health-promoting behaviors and enhance health-related quality of life among participants.

Also known as: TTM-Metaverse Health Education

TTM-Based Metaverse Lifestyle Health Education Arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with first diagnosed colorectal cancer who have undergone radical surgical treatment
• Aged ≥18 years old and non-pregnant
• Have basic communication, reading and comprehension abilities, and can proficiently use smartphones and WeChat
• Voluntarily sign the informed consent form and promise to cooperate in completing all interventions and follow-up assessments

You may not qualify if:

• Patients with other types of malignant tumors
• Patients with incompletely resected tumors or distant metastases
• Patients with dysfunction of important organs such as heart, liver and kidney, or with unstable/rapidly deteriorating conditions
• Patients with severe cognitive impairment who cannot communicate normally and cooperate with the intervention

Sponsors & Collaborators

• Qu Shen: lead

MeSH Terms

Conditions

Colorectal Neoplasms; Health Education; Health Behavior

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Adherence Interventions; Medication Adherence; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Behavior

Central Study Contacts

Xinyu Huang

CONTACT

19509906220; 19509906220@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 27, 2025
• First Posted: January 23, 2026
• Study Start: January 20, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: January 28, 2026

Record last verified: 2026-01