EMDR Treatment of Conditioned Nausea and Vomiting in Cancer Survivors

NCT06769165 | Recruiting

• 1 other identifier: 19946
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

To explore the effectiveness of EMDR therapy treatment in reducing symptoms of chemotherapy-induced conditioned nausea and vomiting in (former) patients with cancer.

Conditions

Cancer Survivors

Keywords

EMDR; Nausea; Vomiting

Outcome Measures

Primary Outcomes (1)

• Degree of conditioned nausea and vomiting

  Degree of conditioned nausea and vomiting after exposure to conditioned stimuli using the nausea profile questionnaire measured using the nausea profile questionnaire (9-point Likert scale, higher scores = worse outcome)

  Before intake EMDR therapy session and three weeks after last EMDR therapy session

Secondary Outcomes (1)

• Impact on QoL of conditioned nausea and vomiting

  Before EMDR therapy

Study Arms (1)

EMDR Therapy

EXPERIMENTAL

EMDR therapy sessions with a trained psychologist.

Other: EMDR therapy

Interventions

EMDR therapy OTHER

In this study, EMDR therapy will be performed by psychologists of the UMCG who are trained in EMDR therapy and who have experience with patients with somatic diseases. In the EMDR therapy protocol, the patient is guided through eight phases which incorporate dual focus of attention and alternating bilateral visual, auditory, and/or tactile stimulation (see supplement for protocol). The number of sessions varies per patient (1-3 sessions), depending on the desensitization of the conditioned stimuli. The sessions will last 60-90 minutes.

EMDR Therapy

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Previously pathologically confirmed diagnosis of cancer
• Previously treated with systemic cancer therapy
• Persistent complaints (more than 2 months) of conditioned nausea and/or vomiting
• Able to understand spoken and written Dutch
• years or older

You may not qualify if:

• Ongoing psychiatric treatment
• EMDR therapy contraindications (dissociative disorders, personality disorders or severe somatic disorders (e.g. cardiac arrhythmias))
• Complex type 2 trauma
• Known with recent conditions / non-anti-cancer medication which can elicit nausea (e.g. pregnancy or alcohol abuses)

Sponsors & Collaborators

• University Medical Center Groningen: lead

Study Sites (1)

University Medical Center Groningen

Groningen, Provincie Groningen, 9713 GZ, Netherlands

RECRUITING

MeSH Terms

Conditions

Nausea; Vomiting

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jacco J de Haan, MD, PhD

  University Medical Center Groningen

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jacco J de Haan, MD, PhD

CONTACT

+31503616161; j.j.de.haan@umcg.nl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2024
• First Posted: January 10, 2025
• Study Start: July 2, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: December 11, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

NL (1)