Exploring the Effects of Hand and Foot Exercise Intervention in Older Adults With Gynecological Cancer Receiving Chemotherapy Improvement of Peripheral Neuropathy and Quality of Life

NCT07362147 | Not Yet Recruiting

• 1 other identifier: 2025-12-008A
• Study Type: interventional
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

Paclitaxel-based drugs are commonly used adjuvant chemotherapy for gynecological cancer patients. Peripheral neuropathy, a side effect of this treatment, presents with symptoms such as numbness, tingling, decreased skin and reflex sensation, and impaired function in the hands and feet, thus affecting quality of life. Peripheral neuropathy is a side effect caused by the neurotoxicity of certain chemotherapeutic drugs, including paclitaxel and platinum-based drugs, resulting from the cumulative toxicity of specific drug doses. While numerous international studies have confirmed the preventative effects of hand and foot movement interventions, there is a lack of relevant literature in China. Therefore, this study aims to explore the effects of hand and foot movement interventions on elderly gynecological cancer patients undergoing chemotherapy.

Conditions

Cervical Cancer; Endometrial Cancer; Ovarian Cancer; Vaginal Cancers; Peripheral Neuropathy; Fallopian Tube Cancers

Keywords

hand and foot exercises, chemotherapy, gynecological cancer, peripheral neuropathy, quality of life

Outcome Measures

Primary Outcomes (1)

• Peripheral neuropathy

  The content includes FACT/GOG-Ntx variable data.The maximum score is 120 points, and the minimum score is 0 points.A higher score indicates a better result.

  From enrollment to the end of treatment at 12 weeks.

Secondary Outcomes (1)

• Quality of life

  From enrollment to end of treatment (12 weeks)

Study Arms (2)

control group

NO INTERVENTION

experimental group

EXPERIMENTAL

Other: hand and foot exercises

Interventions

hand and foot exercises OTHER

The hand and foot exercise steps include hand and foot movements, practiced in a seated position. Hold each movement for ten seconds and then relax, repeating ten times. Perform the hand and foot exercises three times a day, for 10-15 minutes each time, three days a week, for twelve weeks.

experimental group

Eligibility Criteria

• Age: 65 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Individuals aged 65 or older diagnosed with gynecological cancer (stage II to IV) by a physician, without skin or nail lesions.
• Individuals who have received at least one course of chemotherapy within the past year and have peripheral neuropathy, with chemotherapy drugs including paclitaxel (Paclitaxel or Docetaxel) or platinum-based drugs (Cisplatin or Carboplatin), and may receive combined targeted or immunotherapy.
• Individuals who are conscious and able to communicate in Mandarin, Taiwanese, or written language.

You may not qualify if:

• Skin or nail lesions. Edema of 3+ or more in the extremities. History of diagnosis of diabetes, neuropathy, peripheral arterial ischemia, or multiple organ failure.
• Distal bone or skin metastases. Patients who have interrupted chemotherapy. Patients who have participated in similar studies.

Sponsors & Collaborators

• Taipei Veterans General Hospital, Taiwan: lead

Study Sites (1)

Taipei Veterans General Hospital

Taipei, No.201, Sec. 2, Shipai Rd., Beitou District, 112201, Taiwan

Location

Related Publications (1)

• Eroglu I, Kutluturkan S. The effect of hand-foot exercises on chemotherapy-induced peripheral neuropathy-related pain, falls, and quality of life in colorectal cancer: A randomized controlled trial. Eur J Oncol Nurs. 2024 Aug;71:102641. doi: 10.1016/j.ejon.2024.102641. Epub 2024 Jun 15.

  PMID: 38897103 RESULT

Related Links

• This study followed the hand and foot movement guidelines recommended by Eroglu \& Kutluturkan (2024). Because the guidelines are relevant to the specific conditions of the cases in this study.

MeSH Terms

Conditions

Peripheral Nervous System Diseases; Uterine Cervical Neoplasms; Endometrial Neoplasms; Ovarian Neoplasms; Vaginal Neoplasms; Fallopian Tube Neoplasms

Condition Hierarchy (Ancestors)

Neuromuscular Diseases; Nervous System Diseases; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Endocrine Gland Neoplasms; Ovarian Diseases; Adnexal Diseases; Endocrine System Diseases; Gonadal Disorders; Vaginal Diseases; Fallopian Tube Diseases

Study Officials

• CHANG Chen Hsuan

  STUDY CHAIR

Central Study Contacts

CHANG Chen Hsuan

CONTACT

+886 975800615; xuan851119@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: The experimental group received 12 weeks of hand and foot movement interventions (10-15 min/session \* 3 sessions/week).

Study Record Dates

• First Submitted: January 7, 2026
• First Posted: January 23, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): November 30, 2026
• Study Completion (Estimated): November 30, 2027
• Last Updated: January 23, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)