NCT07361185

Brief Summary

A single-center, cluster-randomized controlled trial was conducted to determine the effect of Sticker reminder intervention on IV-to-PO switching of fluoquinolone.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
168

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2020

Completed
4.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

January 4, 2026

Completed
18 days until next milestone

First Posted

Study publicly available on registry

January 22, 2026

Completed
Last Updated

January 22, 2026

Status Verified

January 1, 2026

Enrollment Period

4.5 years

First QC Date

January 4, 2026

Last Update Submit

January 14, 2026

Conditions

FluoroquinoloneAdult

Keywords

Antimicrobial stewardshipFluoroquinoloneAntibiotic

Outcome Measures

Primary Outcomes (1)

  • IV-to-PO switching

    Proportion of patients who underwent switching from intravenous fluoroquinolone to oral fluoroquinolone within the same hospitalization

    From the day of initiation of fluoroquinolone to the discharge date (Up to 1 year)

Secondary Outcomes (2)

  • Length of stay

    From the day of initiation of intravenous fluroquinolone to the day of discharge (up to 1 year)

  • Duration of FQ therapy

    From the first day to the last day of fluroquinolone use (up to 1 year)

Study Arms (2)

Standard of care

NO INTERVENTION

No AMs intervention

Sticker reminder arm

EXPERIMENTAL

Sticker reminder

Behavioral: Sticker reminder

Interventions

Sticker reminderBEHAVIORAL

a reminder sticker was applied to the vital signs sheet of patients meeting predefined switching criteria

Sticker reminder arm

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patients (aged ≥ 18 years)
  • Diagnosis of any infection
  • Receiving at least one dose of intravenous fluoroquinolones (ciprofloxacin, levofloxacin, or moxifloxacin)

You may not qualify if:

  • Inability to tolerate oral medications (e.g., due to severe nausea/vomiting, malabsorption, active gastrointestinal bleeding, or severe diarrhea);
  • Being in an immunodeficiency state (e.g., neutropenia \[absolute neutrophil count ≤ 500 cells/mm3\], symptomatic HIV/AIDS, history of bone marrow or organ transplantation, leukemia, or current use of immunosuppressive agents); or
  • Having severe infections requiring exclusive intravenous antimicrobial therapy (e.g., infective endocarditis, meningitis, encephalitis, brain abscess, or prosthetic device infections).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Medicine Siriraj Hospital

Bangkok, Bangkok, 10700, Thailand

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 4, 2026

First Posted

January 22, 2026

Study Start

July 1, 2020

Primary Completion

December 31, 2024

Study Completion

December 31, 2024

Last Updated

January 22, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

TH(1)