Effect of Diluted Thyme Honey On Dry Mouth In Intensive Care Unit Patients Exposed to Oxygen Flow Therapy

NCT07358494 | Completed

• 1 other identifier: AnkaraU-esrayaprakgokturk01
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This research is a randomized, controlled, double-blind, experimental study conducted to investigate the effect of diluted thyme honey on dry mouth in individuals receiving treatment in intensive care and receiving nasal oxygen flow therapy. H0: There is no significant difference in reducing dry mouth in intensive care patients receiving nasal oxygen flow therapy between the intervention group receiving oral care with diluted thyme honey and the control group receiving standard oral care. The study sample consisted of 64 inpatients receiving nasal oxygen flow therapy in the Emergency Intensive Care and Emergency Critical Intensive Care Units of Ankara Training and Research Hospital. Patients were divided into groups using a sealed envelope method. Patients in the intervention group received oral care using diluted thyme honey, while patients in the control group received oral care using 0.9% NaCl.

Conditions

Nursing Care

Keywords

Xerostomia; Thyme Honey; Nursing; Nasal Oxygen Flow Treatment

Outcome Measures

Primary Outcomes (1)

• The Effect of Diluted Thyme Honey on Dry Mouth in Intensive Care Patients Receiving Nasal Oxygen Flow Therapy: A Randomized Controlled Trial

  The Subjective Dry Mouth Assessment Form was used to assess dry mouth. This form includes questions regarding symptoms such as "dry mouth," "difficulty swallowing," "difficulty speaking," "waking up from sleep," "dry tongue," "burning mouth," "burning throat," "dry throat," "thirst," "bad taste in the mouth," "saliva volume," and "bad breath." Responses are scored on a 0-10 scale using 11 Visual Analogue Scales (VAS). Scoring begins with 0 (not at all) and ends with 10 (extremely). The Subjective Dry Mouth Assessment Form was administered to patients before the study began to gather patient information and determine their dry mouth levels. At the end of the third day, the Subjective Dry Mouth Assessment Form was administered to the patients, who underwent three days of treatment, and their dry mouth was re-evaluated. Data on the patients' dry mouth levels were collected before and after the study.

  9 week

Study Arms (2)

diluted thyme honey arm

EXPERIMENTAL

* After obtaining informed consent from participants who agreed to participate in the study, they were asked to draw one sealed envelope from a bag containing sealed envelopes numbered from 1 to 64. The envelopes drawn by the patients were opened in their presence. The researcher determined whether the patients would be included in the intervention or control group based on the number drawn from the envelope. * Participants assigned to the intervention group were first given the Patient Information Form. Then, before starting the intervention, participants were asked questions from the "Subjective Dry Mouth Assessment Form" prepared by Duruk (2012) using the Visual Analogue Scale. Each point given in response to the questions was recorded in the Patient Follow-up Form. * Patients were educated on the importance of dry mouth, the types of foods and liquids to avoid, the necessity of adequate saliva secretion, the functions of saliva, methods of coping with dry mouth, and the necess

Other: diluted thyme honey arm; Other: Mouth wash

0.9% NaCl arm

PLACEBO COMPARATOR

After obtaining informed consent from participants who agreed to participate in the study, they were asked to draw one sealed envelope from a bag containing sealed envelopes with numbers ranging from 1 to 64 written on them. The envelopes drawn by the patients were opened in their presence. Patients were assigned to either the intervention or control group according to the number drawn from the envelope. * Participants in the control group were first given the Patient Information Form. Then, before starting the application, they were asked questions from the Subjective Dry Mouth Assessment Form. Each point given in response to the questions was recorded in the Patient Follow-up Form. * Patients were educated on the importance of dry mouth, the types of foods and liquids to avoid, the necessity of adequate saliva secretion, the functions of saliva, methods for coping with dry mouth, and the necessary precautions to identify and report any side effects that

Other: Mouth wash

Interventions

Mouth wash OTHER

In this study, the usability of an alternative method for the elimination of dry mouth, which has a very important place in terms of nursing care, was investigated. The effect of diluted thyme honey on dry mouth in intensive care patients receiving nasal oxygen flow therapy, which has not been previously studied in the literature, was investigated.

0.9% NaCl arm; diluted thyme honey arm

diluted thyme honey arm OTHER

In this study, the feasibility of an alternative method for alleviating dry mouth, which is very important in terms of nursing care, was investigated. The effect of diluted thyme honey, which had not been previously studied, on dry mouth was investigated in intensive care patients receiving nasal oxygen flow therapy in the intervention group. The control group received oral care using a standard oral care solution of 0.9% NaCl.

diluted thyme honey arm

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Being treated under intensive care conditions and receiving nasal oxygen flow therapy above 4L/min,
• Over 18 years of age,
• Not diagnosed with Sjögren's Syndrome,
• No previous exposure to radiotherapy or chemotherapy,
• Has not had a salivary gland infection,
• Has not undergone an operation to remove the salivary glands,
• Not allergic to honey,
• No chewing or swallowing difficulties,
• Not using thyme-containing products for oral care in the previous period,
• Patients who did not have any communication problems and who voluntarily agreed to participate in the study were included in the study

Sponsors & Collaborators

• Esra Yaprak Gokturk: lead

Study Sites (1)

Ankara University Institute of Health Sciences Department of Nursing

Ankara, Dışkapı, 6070, Turkey (Türkiye)

Location

Related Publications (35)

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MeSH Terms

Conditions

Xerostomia

Interventions

Mouthwashes

Condition Hierarchy (Ancestors)

Salivary Gland Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Biomedical and Dental Materials; Specialty Uses of Chemicals; Chemical Actions and Uses; Cosmetics; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• ayten demir, assoc.prof.dr.

  Ankara University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Masking Details: Randomization Participants included in the study were assigned to the intervention or control groups using a simple randomization method involving envelopes. Numbers ranging from 1 to 64, representing patient numbers, were automatically distributed at random via the website https://www.calculatorsoup.com/calculators/statistics/random-number-generator.php, thereby creating "Set 1." It was determined that the first 32 of the 64 randomly arranged numbers in 'Set 1' would represent patients in the intervention group, and the last 32 would represent patients in the control group. After obtaining consent from the patients participating in the study, they were asked to draw one sealed envelope from a bag containing sealed envelopes with numbers from 1 to 64 written on them. The envelopes drawn by the patients were opened in their presence. The researcher determined which group the patients would be included in, either the intervention or control group, based on the number that came out of the
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MSN: Master of Science in Nursing

Model Details: This study has a randomized controlled experimental design.

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: January 22, 2026
• Study Start: October 1, 2022
• Primary Completion: November 30, 2022
• Study Completion: November 30, 2022
• Last Updated: January 22, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE

Locations

TU (1)