The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique

NCT07351435 | Not Yet Recruiting

• 1 other identifier: 18-11-2025 CHUM CVT
• Study Type: observational
• Target: 1,200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana. All patients undergoing ECMO implantation will be prospectively registered.

Conditions

Cardiogenic Shock; Malignant Arrhythmias; Ischemic or Valvular Heart Failure; Drepanocytosis and Thoracic Syndrome; Pulmonary Thromboembolisms; Sepsis; ARDS (Acute Respiratory Distress Syndrome); Intoxication; Cardiac Arrest (CA); Postcardiotomy Heart Failure; Acute Respiratory Failure

Keywords

acute heart failure; respiratory insufficiency

Outcome Measures

Primary Outcomes (1)

• Mortality at 30 days

  Number of deceased participants as assessed at 30 days after ECMO implantation

  from canula implantation to 30 days afterwards

Secondary Outcomes (1)

• Number of participants with major adverse events

  From canula implantation to up to 6 months after ECMO implantation

Study Arms (3)

VV-ECMO

Patients with respiratory failure

VA-ECMO

Patients with cardiac failure or combined cardiopulmonary failure

VAV-ECMO

Patients initially on VV or VA-ECMO who require additional respiratory/circulatory support

Eligibility Criteria

• Age: Up to 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients implanted with a VV-ECMO, VA-ECMO or VAV-ECMO device by the UHM HeartTeam

You may qualify if:

• All consecutive patients implanted with a veno-venous extracorporeal membrane oxygenation device or extracorporeal membrane oxygenation device by the HeartTeam from the University Hospital of Martinique (UHM) from January 2010

You may not qualify if:

• Patients with incomplete data (primary endpoint and less than 80% secondary study outcomes)

Sponsors & Collaborators

• University of Genova: lead

Related Publications (10)

• Serpa Neto A, Higgins AM, Bailey MJ, Anderson S, Bernard S, Fulcher BJ, Jones A, Linke NJ, Board JV, Brodie D, Buhr H, Burrell AJC, Cooper DJ, Fan E, Fraser JF, Gattas DJ, Hopper IK, Huckson S, Litton E, McGuinness SP, Nair P, Orford N, Parke RL, Pellegrino VA, Pilcher DV, Dicker C, Reddi BAJ, Stub D, Trapani TV, Udy AA, Hodgson CL; EXCEL Study Investigators on behalf of the International ECMO Network (ECMONet). Long-Term Functional Outcomes in the First 12 Months After VA-ECMO in Adult Patients: A Prospective, Multicenter Study. Circ Heart Fail. 2025 Jun;18(6):e012476. doi: 10.1161/CIRCHEARTFAILURE.124.012476. Epub 2025 Apr 29.

  PMID: 40298907 BACKGROUND

• Ling RR, Chen Y, Low CJW, Agerstrand C, Jung JS, Lim SL, Lorusso R, Mueller T, Okada Y, Tonna JE, Shekar K, Brodie D, MacLaren G, Ramanathan K. Left ventricular unloading during extracorporeal cardiopulmonary resuscitation: a target trial emulation of the ELSO registry. Crit Care. 2025 May 8;29(1):186. doi: 10.1186/s13054-025-05345-3.

  PMID: 40340843 BACKGROUND

• Grazioli A, Plazak M, Willsey K, Rabin J, Rector RP, Belyayev L, Lankford AS, Scalea TM, Shah A, Taylor BS, Gladwin MT. Outcomes and survival prediction in adults with sickle cell disease treated with extracorporeal membrane oxygenation. Blood Adv. 2025 Oct 14;9(19):4881-4890. doi: 10.1182/bloodadvances.2025016368.

  PMID: 40644625 BACKGROUND

• Labrada L, Alarfaj M, Tran L, Granger H, Hernandez A, Hu J, Baker J, Grandin EW, Delgado AA, Katz JN, Miller PE, Alviar CL, Osborn E, Bacchetta MD, Lindenfeld J, Shah Z, Rali AS. Optimal ECLS Support in Mixed Cardiogenic and Septic Shock: An ELSO Registry Analysis. JACC Adv. 2025 Oct;4(10 Pt 1):101965. doi: 10.1016/j.jacadv.2025.101965. Epub 2025 Jul 23.

  PMID: 40704940 BACKGROUND

• Wang L, Wang K, Wang Y, Yang F, Li C, Hao X, Du Z, Rycus PT, Tonna JE, Fan E, Wang H, Hou X. A simple VA-ECMO bundle in adult patients with cardiogenic shock: an analysis of ELSO registry. EClinicalMedicine. 2025 Aug 7;87:103423. doi: 10.1016/j.eclinm.2025.103423. eCollection 2025 Sep.

  PMID: 40823501 BACKGROUND

• Baldetti L, Pontillo D, Capoccia M, Kowalewski M, Tonna JE, Broman M, Conrad SA, Swol J, Scandroglio AM, Brewer JM, Maybauer MO, Lorusso R. Venopulmonary extracorporeal life support: An Extracorporeal Life Support Organization registry analysis. J Heart Lung Transplant. 2026 Jan 6:S1053-2498(25)02480-5. doi: 10.1016/j.healun.2025.12.024. Online ahead of print.

  PMID: 41506589 BACKGROUND

• Moynihan KM, Sharma M, Mehta A, Lillie J, Ziegenfuss M, Festa M, Chan T, Thiagarajan R. Race-Conscious Research Using Extracorporeal Life Support Organization Registry Data: A Narrative Review. ASAIO J. 2024 Sep 1;70(9):721-733. doi: 10.1097/MAT.0000000000002206. Epub 2024 Apr 18.

  PMID: 38648078 BACKGROUND

• Remy T, Jegard J, Chenouard A, Maminirina P, Liet JM, Couec ML, Joram N, Bourgoin P. Characteristics and outcomes of children and young adults with sickle cell disease supported with extracorporeal membrane oxygenation (ECMO): An updated analysis of the ELSO registry. Artif Organs. 2025 Mar;49(3):508-515. doi: 10.1111/aor.14880. Epub 2024 Oct 3.

  PMID: 39360897 BACKGROUND

• Mazzeffi M, Zaaqoq A, Curley J, Buchner J, Wu I, Beller J, Teman N, Glance L. Survival After Extracorporeal Cardiopulmonary Resuscitation Based on In-Hospital Cardiac Arrest and Cannulation Location: An Analysis of the Extracorporeal Life Support Organization Registry. Crit Care Med. 2024 Dec 1;52(12):1906-1917. doi: 10.1097/CCM.0000000000006439. Epub 2024 Oct 9.

  PMID: 39382377 BACKGROUND

• Kanwar MK, Shah P, Cascino T, Grinstein J, Goldstein D, Hernandez-Montfort J, Li S, Uriel N, Molina E, Cantor R, Komanduri B, Pagani FD, Kirklin JK. Impact of Preoperative Temporary Mechanical Circulatory Support on Durable LVAD Outcomes: An Analysis of The Society of Thoracic Surgeons National Intermacs Database. JACC Heart Fail. 2025 Nov;13(11):102671. doi: 10.1016/j.jchf.2025.102671. Epub 2025 Oct 8.

  PMID: 41193107 BACKGROUND

MeSH Terms

Conditions

Shock, Cardiogenic; Ischemia; Sickle Cell Trait; Pulmonary Embolism; Sepsis; Acute Lung Injury; Heart Arrest; Respiratory Insufficiency

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Shock; Anemia, Sickle Cell; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Lung Injury; Respiration Disorders

Study Officials

• Marc LICKER, BC

  CHU Martinique

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Marc LICKER, MD

CONTACT

+41796234488; marc.licker@unige.ch

Jeremy MAZILE, BC perfusionnist

CONTACT

jermy.bazile@chu-martinique.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Honorary Professor at the University of Geneva, Consultant in the department of Cardiothoracic Anesthesia and Critical Care at the University Hospital of Martinique

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: January 20, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): December 31, 2032
• Study Completion (Estimated): June 30, 2033
• Last Updated: January 20, 2026

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: from January 2026 to December 2032