Peripersonal Space Representation in Upper Limb Segmental Exclusion

NCT07349173 | Recruiting DMC

• 2 other identifiers: IRR-CLP-2023-32025-A02189-40
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects. Segmental exclusion is defined by non-use or under-use of a limb segment without central nervous system damage. The study hypothesizes that this syndrome leads to a modification (shrinkage) of the PPS representation. Participants will perform reachability judgments in a Virtual Reality (VR) environment.

Conditions

Segmental Exclusion Syndrome; Complex Regional Pain Syndrome (CRPS); Upper Limb Neglect (Peripheral)

Keywords

Peripersonal Space; Virtual Reality; Body Schema; Reachability Judgment

Outcome Measures

Primary Outcomes (1)

• Judgment Error of Reachability

  The Judgment Error of Reachability is a single composite metric calculated as: ((DMA-p - DMA-r) / DMA-r) × 100, expressed as a percentage (%). Both DMA-p (Perceived Maximum Reachable Distance) and DMA-r (Real Maximum Reachable Distance) are measured in centimeters, and their ratio yields a single dimensionless percentage score.

  Day 1 (During the 40-minute VR assessment)

Secondary Outcomes (5)

• Body Perception Disturbance Score

  Day 1 (Before VR task)

• Functional Impairment Score (400-Point Hand Assessment)

  Day 1

• Anxiety and Depression Score (HAD)

  Day 1

• Kinesiophobia Score (Tampa Scale)

  Day 1

• Pain Catastrophizing Score (PCS)

  Day 1

Study Arms (2)

Patients with Exclusion

Patients presenting with unilateral segmental exclusion of the upper limb or part of the hand evolving for more than 3 months.

Behavioral: Reachability Judgment Task in VR.

Healthy Controls

symptomatic volunteers with no history of upper limb impairment with sequelae.

Behavioral: Reachability Judgment Task in VR.

Interventions

Reachability Judgment Task in VR. BEHAVIORAL

Participants wear an Oculus Quest 2 VR headset. They first perform a motor task to measure Real Reachable Distance (DMA-r). Then, they perform a perceptual task where they must judge, without moving, if a virtual object is reachable (DMA-p). The test evaluates different spatial planes (front, 45° right, 45° left) and heights (shoulder, navel).

Healthy Controls; Patients with Exclusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

he study population consists of two groups recruited at the Institut Régional de Réadaptation (Centre Louis Pierquin, UGECAM Nord-Est) in Nancy, France. Patients with Exclusion: Participants are selected from patients receiving routine care (full hospitalization or day hospital) at the center. They are identified based on a functional assessment ("Bilan 400 points") showing specific impairments related to unilateral upper limb exclusion evolving for more than 3 months. Healthy Controls: Asymptomatic volunteers are recruited through the social or family network of the investigators and current participants, as well as via posters displayed in the UGECAM centers.

You may qualify if:

• Age ≥ 18 years.
• No contraindication to force work in daily activities.

You may not qualify if:

• Affiliated to a social security scheme.
• Able to understand simple orders.
• Age ≥ 18 years.
• No history of upper limb impairment with sequelae.
• Visual impairments.
• Central neurological pathology.
• Unstabilized psychiatric pathology.
• Communication or comprehension difficulties.
• Under legal protection or unable to consent.
• Pregnant or breastfeeding women.
• Cervical pathology contraindicating VR headset use.
• Epilepsy.
• Inability to stand for 40 minutes.

Sponsors & Collaborators

• Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est: lead

Study Sites (1)

Institut Régional de Médecine Physique et de Réadaptation (IRR), Centre Louis Pierquin.

Nancy, 54000, France

RECRUITING

MeSH Terms

Conditions

Complex Regional Pain Syndromes; Personal Space

Condition Hierarchy (Ancestors)

Autonomic Nervous System Diseases; Nervous System Diseases; Peripheral Nervous System Diseases; Neuromuscular Diseases; Spatial Behavior; Behavior

Central Study Contacts

Amélie Touillet, MD

CONTACT

+33 3 83 52 98 80; amelie.touillet@ugecam.assurance-maladie.fr

Jonahtan Pierret, PhD

CONTACT

+33 3 83 52 67 61; jonathan.pierret@ugecam.assurance-maladie.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2026
• First Posted: January 16, 2026
• Study Start: December 4, 2025
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): January 1, 2028
• Last Updated: March 16, 2026

Record last verified: 2026-03

Locations

FR (1)