Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score

NCT07093424 | Completed

• 1 other identifier: RSD1
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

Complex Regional Pain Syndrome (CRPS) is a condition triggered by trauma such as surgery or a fracture. It is characterised by pain and limited mobility that are disproportionate to the severity of the trauma and the clinical course. Magnesium is recognised for its anti-inflammatory and antioxidant properties. The magnesium depletion score (MDS) is a more reliable and comprehensive scoring tool than measuring serum and urine magnesium levels. This score takes into account the patient's use of diuretics and proton pump inhibitors, their alcohol consumption, and their glomerular filtration rate. Impaired magnesium distribution may be a risk factor for CRPS development due to increased nociceptor activity. This study aimed to investigate whether an increased MDS score is a risk factor for CRPS development in individuals with traumatic limb injury.

Conditions

Complex Regional Pain Syndrome (CRPS)

Outcome Measures

Primary Outcomes (1)

• CRPS development

  crps development will be assessed according to Budapest criteria

  baseline

Study Arms (1)

traumatic extremity injury

Other: scoring

Interventions

scoring OTHER

magnesium depletion score calculation

traumatic extremity injury

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients admitted to our hospital's physical therapy and rehabilitation outpatient clinics with traumatic extremity injuries

You may qualify if:

• Male and female patients aged 18-99 years with traumatic extremity injuries

You may not qualify if:

• History of previous stroke, spinal cord injury
• Presence of radiculopathy, radicular pain in the affected extremity
• Previous surgery for cervical discopathy/lumbar discopathy
• Presence of oncological, haematological diseases
• History of previous peripheral nerve injury or previous surgery

Sponsors & Collaborators

• Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization: lead

Study Sites (1)

Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi

Şişli, Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Complex Regional Pain Syndromes

Condition Hierarchy (Ancestors)

Autonomic Nervous System Diseases; Nervous System Diseases; Peripheral Nervous System Diseases; Neuromuscular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Specialist, principal investigator

Study Record Dates

• First Submitted: June 30, 2025
• First Posted: July 30, 2025
• Study Start: January 1, 2025
• Primary Completion: January 1, 2025
• Study Completion: June 1, 2025
• Last Updated: July 30, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

TU (1)