Characterization of Opposition to Organ Donation at Strasbourg University Hospital in 2024-2025

NCT07345975 | Recruiting

• 1 other identifier: 9824
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

In 2024, 29,000 people are waiting for organ transplants in France, and only 6,034 transplants were performed during the year. 852 people died while waiting for a transplant. The gap between the number of available transplants and the number of patients waiting for transplants has been widening since the 1990s; there is talk of a shortage of transplants. There is therefore an urgent need to find more transplants and mobilize the entire population to this end. French law supports presumed consent, meaning that we are all donors unless we have expressed otherwise during our lifetime. In fact, 80% of French people say they are in favor of organ donation after their death, but few discuss it with their loved ones. When families are approached about multi-organ removal to gather any opposition from the deceased, the refusal rate is 37% (compared to an expected 20%). It is difficult to determine whether this opposition truly comes from the deceased themselves, their loved ones, uncertainty, or the situation. As this is the leading cause of non-donation, it is essential to better characterize this opposition in order to reduce it and allow for more organ donation and, ultimately, transplantation.

Conditions

Organ Donation

Keywords

Organ Donation; Organ transplant

Outcome Measures

Primary Outcomes (1)

• Distribution of positions regarding organ donation (certain, uncertain, unknown)

  Distribution of positions regarding organ donation (certain, uncertain, unknown): For illustration purposes: * Certain position: ≈ 65% * Favorable: ≈ 55% * Opposed: ≈ 10% * Uncertain position: ≈ 25% * Unknown/unexpressed position: ≈ 10%

  Up to 12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are brain dead and/or eligible for a Maastricht 3 protocol (discontinuation of active treatment with death due to circulatory arrest in intensive care)

You may qualify if:

• Patients who are brain dead and/or eligible for a Maastricht 3 protocol (discontinuation of active treatment with death due to circulatory arrest in intensive care)
• Hospitalized in the intensive care unit of the Strasbourg University Hospital or transferable to the Strasbourg University Hospital for multi-organ removal (anticipated approach)
• Existence of relatives with whom discussion is possible
• Presence of organ procurement coordination at the initial donation interview

You may not qualify if:

• Absence of relatives of the deceased (no interview with them)
• Absence of organ procurement coordination during the initial discussion with relatives regarding organ and tissue procurement

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service d'Anesthésie, Réanimation et Médecine Périopératoire - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

Central Study Contacts

Charlotte POUSSARDIN, MD

CONTACT

33 3.69.55.16.21; charlotte.poussardin@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 7, 2026
• First Posted: January 16, 2026
• Study Start: October 14, 2025
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 14, 2027
• Last Updated: January 16, 2026

Record last verified: 2026-01

Locations

FR (1)