Effect of Indoor Air Quality Improvement on Health in Patients With Interstitial Lung Disease

NCT07344987 | Not Yet Recruiting

• 1 other identifier: CAMS-PUMC-IRM-IAQ-ILD-2025
• Study Type: interventional
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Air pollution threatens the respiratory health of patients with interstitial lung disease (ILD). High-efficiency air purifiers, featuring easy operation and excellent particulate matter removal efficiency, have been shown in previous studies to potentially delay lung function deterioration and reduce acute exacerbation risk in respiratory disease patients. This randomized crossover study employs air purifiers to filter indoor gaseous pollutants, allergens, and other contaminants, aiming to alleviate respiratory irritation, improve daily life comfort, and enhance overall health status in ILD patients.

Conditions

ILD

Outcome Measures

Primary Outcomes (4)

• Symptom Improvement-related Indicators (e.g., Improvement in Respiratory Symptom Score)

  St. George's Respiratory Questionnaire (SGRQ):Score Range:Minimum score: 0 points;Maximum score: 100 points.A higher score indicates worse outcomes for the patient.

  Baseline (before intervention), Week 2 (end of first phase), Week 6 (end of second phase)

• Pulmonary Function Indicators (e.g., Pulmonary Diffusing Capacity)

  Baseline (before intervention), Week 2 (end of first phase), Week 6 (end of second phase)

• Quality of Life Indicators (e.g., CAT Score)

  COPD Assessment Test (CAT):It is a short, validated, patient-reported outcome (PRO) tool specifically designed to measure the impact of pulmonary disease on a patient's health status and daily life.Score Range:Minimum score: 0 points;Maximum score: 40 points.A higher score indicates worse health status and greater pulmonary disease-related burden for the patient.

  Baseline (before intervention), Week 2 (end of first phase), Week 6 (end of second phase)

• Blood Sample Indicators (e.g., Concentration of Interleukin-8)

  Assessment of Changes in Pulmonary Inflammation or Lung Injury Before and After Intervention Using Concentrations of Biomarkers Such as Interleukin-8

  Baseline (before intervention), Week 2 (end of first phase), Week 6 (end of second phase)

Study Arms (2)

Purifier (without Filter) Arm

SHAM COMPARATOR

Behavioral: Purifier (without Filter) Arm

Air Purifier (with Filter) Arm

EXPERIMENTAL

Behavioral: Air Purifier (with Filter) Arm

Interventions

Air Purifier (with Filter) Arm BEHAVIORAL

Place an air purifier with high-efficiency filters in the home, and turn it on for at least 18 hours every day.

Air Purifier (with Filter) Arm

Purifier (without Filter) Arm BEHAVIORAL

Place an air purifier without a filter in the home.

Purifier (without Filter) Arm

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed with interstitial lung disease (ILD).
• Stable disease status, defined as no hospitalization due to acute exacerbation within the past month.

You may not qualify if:

• Patients with complications of severe organ failure (including heart, liver, or kidney failure), malignant tumors, or mental disorders.
• A history of respiratory tract infection within the past two weeks.

Sponsors & Collaborators

• Peking Union Medical College: lead

MeSH Terms

Interventions

Air Filters

Intervention Hierarchy (Ancestors)

Filtration; Chemistry Techniques, Analytical; Investigative Techniques; Equipment and Supplies

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: December 22, 2025
• First Posted: January 15, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share