Misdiagnosis Between Interstitial Lung Disease and Cardiac Patients

NCT06198608 | Unknown

• 1 other identifier: ILD&Cardiac patient
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aim of the study To determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial High Resolution CT interpretation alone. To identify specific HRCT findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition. To establish diagnostic criteria or HRCT patterns that distinguish cardiac congestion from interstitial lung disease

Conditions

ILD

Outcome Measures

Primary Outcomes (1)

• Accuracy of initial HRCT interpretation

  (percentage of cases initially read as interstitial lung disease that were later found to be cardiac congestion)

  baseline

Secondary Outcomes (1)

• Time to correct diagnosis

  baseline

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

prospective observational study design. Inclusion of patients who underwent HRCT for suspected interstitial lung disease or cardiac congestion. HRCT scans by experienced radiologists who are blinded to the initial interpretation and final diagnosis. Development of specific diagnostic criteria or guidelines to differentiate between interstitial lung disease and cardiac congestion based on HRCT findings. Collection of echocardiogram,lab results, clinical follow up to determine finial diagnosis. Comparison of Initial HRCT Interpretation: Comparison of the initial HRCT interpretation with the final diagnosis to determine the rate of misdiagnosis.

You may qualify if:

• Patients who underwent HRCT imaging of the chest for evaluation of suspected interstitial lung disease
• Initial radiology report included a definitive diagnosis of interstitial lung disease patterns
• Age 18+ years
• No prior history of pulmonary or cardiac

You may not qualify if:

• Inconclusive or unclear initial HRCT report
• Underlying diagnosis other than interstitial lung disease or cardiac congestion

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Nathan SD, Pastre J, Ksovreli I, Barnett S, King C, Aryal S, Ahmad K, Fukuda C, Ramalingam V, Chung JH. HRCT evaluation of patients with interstitial lung disease: comparison of the 2018 and 2011 diagnostic guidelines. Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620968496. doi: 10.1177/1753466620968496.

  PMID: 33121391 BACKGROUND

• Case AH, Beegle S, Hotchkin DL, Kaelin T, Kim HJ, Podolanczuk AJ, Ramaswamy M, Remolina C, Salvatore MM, Tu C, de Andrade JA. Defining the pathway to timely diagnosis and treatment of interstitial lung disease: a US Delphi survey. BMJ Open Respir Res. 2023 Nov 24;10(1):e001594. doi: 10.1136/bmjresp-2022-001594.

  PMID: 38007235 BACKGROUND

Study Officials

• marwan sayed, MD

  lecture in cardiac diseases

  STUDY CHAIR

• samaa elkossi, MD

  Lecture inradiology departement

  STUDY CHAIR

Central Study Contacts

Hend saleh, MD

CONTACT

01098988712; hend.m.saleh@gmail.com

Mohamed Abdalrahman, MD

CONTACT

0102660007; dr.mga2011@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: December 26, 2023
• First Posted: January 10, 2024
• Study Start: January 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 30, 2024
• Last Updated: January 10, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share