ILD In Obese Patients With OSA

NCT06503757 | Not Yet Recruiting

• 1 other identifier: ILD &OSA
• Study Type: observational
• Target: 94
• Locations: 0 countries
• Sites: N/A

Brief Summary

Assess the impact of obesity and OSA on the interpretation of high-resolution computed tomography (HRCT) findings in patients with ILD. Identify specific challenges or confounding factors that may contribute to the misinterpretation of HRCT findings in this population. Evaluate the potential consequences of misinterpretation, including delayed or inaccurate diagnosis, inappropriate treatment decisions, and suboptimal patient outcomes.

Conditions

ILD

Outcome Measures

Primary Outcomes (1)

• the prevalence of misinterpretation of interstitial lung disease (ILD) on high-resolution computed tomography (HRCT) scans in obese patients with obstructive sleep apnea (OSA).

  determined by assessing the agreement between radiologists' interpretations of HRCT findings related to ILD in this specific patient population.

  Baseline

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

collect relevant demographic and clinical data, including age, gender, BMI, OSA severity, ILD subtype (if available), pulmonary function test results, and details of previous treatments. 2\. HRCT Scans: HRCT images of the selected patients will be retrieved from the Picture Archiving and Communication System (PACS) or electronic medical record system. 1\. Radiological Assessment: will independently review the HRCT scans. They will assess the presence and extent of ILD, evaluate the specific radiological patterns (e.g., ground-glass opacities, reticular opacities, honeycombing), and record any other notable findings.

You may qualify if:

• Presence of obesity, defined by body mass index (BMI) ≥30 kg/m².
• Confirmed diagnosis of OSA based on polysomnography
• Availability of HRCT scans for analysis

You may not qualify if:

• OSA in non obese patients
• History of lung surgery or lung transplantation.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Khor YH, Ryerson CJ, Landry SA, Howard ME, Churchward TJ, Edwards BA, Hamilton GS, Joosten SA. Interstitial lung disease and obstructive sleep apnea. Sleep Med Rev. 2021 Aug;58:101442. doi: 10.1016/j.smrv.2021.101442. Epub 2021 Jan 22.

  PMID: 33561604 BACKGROUND

• Schiza SE, Bouloukaki I, Bolaki M, Antoniou KM. Obstructive sleep apnea in pulmonary fibrosis. Curr Opin Pulm Med. 2020 Sep;26(5):443-448. doi: 10.1097/MCP.0000000000000697.

  PMID: 32701670 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: July 10, 2024
• First Posted: July 16, 2024
• Study Start: July 20, 2024
• Primary Completion: December 20, 2024
• Study Completion: January 20, 2025
• Last Updated: July 16, 2024

Record last verified: 2024-07