Single Dose Preemptive Paracetamol or Ibuprofen Before Septrorhinoplasty on Intra- and Postoperative Opioid Consumption.

NCT07337629 | Recruiting

• 1 other identifier: GOKAEK 2025/22/11
• Study Type: observational
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

Reducing intra- and postoperative pain or using less opioids is an essential strategy in today's operations. One emerging and widely used method in this context is the use of preemptive analgesic medication. Paracetamol and ibuprofen used preemptively have been shown to reduce postoperative opioid use and pain scores. There are also studies showing that preemptive analgesia with different analgesic medications reduces opioid consumption and postoperative pain. Our study will evaluate both the intraoperative and postoperative effectiveness of paracetamol and ibupurofen with preemptive analgesia, considering total opioid use. It will also investigate drug side effects and their advantages using a 15-question compilation quality scale, validated in Turkish.

Conditions

Analgesia

Keywords

SEPTORHİNOPLASTY; PREEMPTİVE; PARACETEMOL; IBUPROFEN

Outcome Measures

Primary Outcomes (3)

• ANALGESIA

  24-HOUR CUMULATIVE OPIOID CONSUMPTION

  24 HOURS

• COMPILATION

  POSTOPERATIVE QUALITY OF RECOVERY-15 SCALE

  POSTOPERATIVE 24TH HOUR

• PAIN SCORE

  PAIN WILL BE ASSESSED POSTOPERATIVELY AT 0, 1, 6, 12, and 24 HOURS, BOTH AT REST AND DURING ACTIVITY (COUGHING AND DEEP BREATHING), USING THE NRS (Numeric Rating Scale).

  24 HOURS

Study Arms (3)

GROUP P

PARACETEMOL

GROUP I

IBUPROFEN

GROUP K

CONTROL

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

PATIENTS UNDERGOING SEPTORINOPLASTY SURGERY

You may qualify if:

• Septorhinoplasty surgery
• ASA1-2 patients
• Men and women aged 18-65
• Informed consent and acceptance to participate in the study

You may not qualify if:

• ASA 3-4 and under 18 years of age
• Patients with serious renal, hepatological, cardiovascular, or pulmonary system diseases
• Allergy to paracetamol or ibuprofen
• Patients with bleeding diathesis, platelet dysfunction, GI disease, peptic ulcers, pregnancy, planning pregnancy, and breastfeeding mothers
• Patients using ASA or anticoagulants

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun University Samsun Training and Research Hospital

Samsun, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Alshehri AA. Comparative Evaluation of Postoperative Pain Scores and Opioid Consumption in Septorhinoplasty After Administration of Single-Dose Preemptive Paracetamol and Ibuprofen: A Randomized Controlled Trial. Int Arch Otorhinolaryngol. 2023 Aug 4;27(3):e471-e477. doi: 10.1055/s-0042-1749386. eCollection 2023 Jul.

  PMID: 37564463 BACKGROUND

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Hasan Cetinkaya, M.D.

  Samsun University Samsun Educational and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hasan Cetinkaya, M.D.

CONTACT

5464799240; drhasancetinkaya@gmail.com

Caner Genc, M.D.

CONTACT

5444846865; dr.canergenc@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 2, 2026
• First Posted: January 13, 2026
• Study Start: November 24, 2025
• Primary Completion (Estimated): November 24, 2026
• Study Completion (Estimated): November 24, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

TU (1)