Effect of Knee Extensor Training on the Lumbar Spine

NCT07337213 | Not Yet Recruiting

• 1 other identifier: LUC/RADMIN/SP/05/903
• Study Type: interventional
• Target: 128
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are: What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP. Participants will:

• Exercise three times per week for 8 weeks
• Be assessed before, 4 weeks after, and 8 weeks after intervention

Conditions

Non Specific Low Back Pain

Outcome Measures

Primary Outcomes (1)

• Mean change in the Lumbar lordosis Cobb angle in degrees measured by X-ray

  8 weeks

Secondary Outcomes (4)

• Mean change of LBP intensity from the baseline measured by Numeric Pain Rating Scale

  8 weeks

• Mean change in the quality of Life score as measured by the Oswestry Disability Index

  8 weeks

• Mean change in the muscle strength measured by the Hand-held dynamometer

  8 weeks

• Mean change in the posture control measured by the stare exursion test

  8 weeks

Study Arms (4)

control group

ACTIVE COMPARATOR

lumbar strengthening

Other: back strengthening exercise

Treatment Group I

EXPERIMENTAL

lumbar strengthening exercise and knee CKC exercise

Other: OKC Exercise

Treatment Group II

EXPERIMENTAL

lumbar strengthening exercise and knee CKC exercise

Other: CKC Exercise

Treatment Group III

EXPERIMENTAL

lumbar strengthening exercise and knee OKC and CKC exercise

Other: CKC and OKC Exercise

Interventions

back strengthening exercise OTHER

strengthening exercise to lumbar extensors

control group

OKC Exercise OTHER

knee extensor OKC exercise added to the lumbar strengthening exercise

Treatment Group I

CKC Exercise OTHER

knee extensor CKC exercise added to the lumbar strengthening exercise

Treatment Group II

CKC and OKC Exercise OTHER

knee extensor OKC and CKC exercise added to the lumbar strengthening exercise

Treatment Group III

Eligibility Criteria

• Age: 40 Years - 60 Years
• Gender Eligibility Details: Only males will be recruited for the study
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• I. Males aged 40 to 60 years, II. nonsmokers, III. with normal body mass index IV. of Saudi nationality, V. office workers, VI. suffering from chronic NLBP for 12 weeks or more with a moderate disability according to the Oswestry Disability Index (score of 21 - 40%) moderate activity level according to the Arabic version of the International Physical Activity Questionnaire short form .

You may not qualify if:

• I. Previous spinal surgery, fracture, deformity, or disease. II. Neurological deficit and Lower limb deformity or fracture, or disease. III. Mental or psychological illness. The Arabic version of the Self-Reporting Questionnaire (SRQ-20) developed by the World Health Organization (WHO) to screen for common mental disorders such as depression and anxiety, uses a cut-off score to distinguish between individuals with and without significant psychological distress. A score of 7 or below is generally considered "normal", indicating no significant psychological distress (Al-Subaie et al., 1998).
• IV. Systematic chronic illnesses such as hypertension, cardiac and respiratory disorders, and diabetes mellitus.

Sponsors & Collaborators

• Cairo University: collaborator
• Taif University: collaborator
• Lincoln University College: lead

MeSH Terms

Interventions

Conization

Intervention Hierarchy (Ancestors)

Biopsy; Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• ABDULLAH F ALHUMAYANI

  LUC Malaysia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lamiaa K Elsayyad, Assistant professor

CONTACT

+201095366120; dr.elsayyadlamiaa@gmail.com

Hatem H Allam, Assistant professor

CONTACT

+966543321736; hatem.lamiaa@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: January 13, 2026
• Study Start: February 1, 2026
• Primary Completion: April 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01