Role of Magnetic Resonance Imaging in Diagnosis of Adnexal Cystic Lesions

NCT07334184 | Not Yet Recruiting

• 1 other identifier: Adnexal-Lesions-Radiology-2025
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective study aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in characterizing adnexal cystic lesions and differentiating benign from malignant lesions. MRI findings will be correlated with histopathology, surgical data, laboratory results, or follow-up imaging when surgery is not performed, to improve diagnostic confidence and guide appropriate patient management.

Conditions

Adnexal Lesion

Keywords

adnexal lesions

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of MRI in characterization of adnexal cystic lesions

  Assessment of the diagnostic performance of magnetic resonance imaging (MRI) in differentiating benign from malignant adnexal cystic lesions, using histopathology, intraoperative findings, or follow-up imaging as the reference standard. Diagnostic accuracy will be expressed in terms of sensitivity, specificity, and predictive values.

  From MRI examination until final diagnosis (surgery, histopathology, or follow-up imaging), up to 6 months

Study Arms (1)

adnexal cystic lesions cohort

This group consists of female patients of all ages presenting to the Radiology Department at Sohag University Hospital with adnexal cystic lesions detected on ultrasound. Eligible participants have indeterminate or suspicious ultrasound findings and will undergo MRI for further characterization. MRI findings will be correlated with histopathology, surgical data, laboratory results, or follow-up imaging when surgery is not performed.

Diagnostic Test: Magnetic Resonance Imaging

Interventions

Magnetic Resonance Imaging DIAGNOSTIC_TEST

Magnetic resonance imaging (MRI) of the pelvis will be performed using 1.5T or 3T scanners with a phased-array pelvic coil. The protocol will include axial, sagittal, and coronal T2-weighted images, axial T1-weighted and fat-suppressed T1-weighted images, diffusion-weighted imaging with ADC maps, and dynamic contrast-enhanced sequences when clinically indicated and not contraindicated.

adnexal cystic lesions cohort

Eligibility Criteria

• Gender Eligibility Details: Only biologically female patients with adnexal cystic lesions are eligible, regardless of gender identity.
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of 50 female patients of all ages presenting to the Radiology Department at Sohag University Hospital with adnexal cystic lesions detected on ultrasound. Eligible participants are those with indeterminate or suspicious ultrasound findings requiring further characterization with MRI. Patients will provide written and oral informed consent prior to inclusion.

You may qualify if:

• Female patients of any age with adnexal cystic lesions detected by ultrasound
• Adnexal lesions that are indeterminate or suspicious on ultrasound
• Patients who provide written and oral informed consent

You may not qualify if:

• Patients unwilling to participate or complete the study
• Contraindications to MRI, including claustrophobia, metallic implants, pacemaker, or prosthetic heart valves

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

Location

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Mira Noshey Mehawed Abed El Nor, MBBCH

CONTACT

+01288264655; mera_noshy_post@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: December 31, 2025
• First Posted: January 12, 2026
• Study Start: December 26, 2025
• Primary Completion (Estimated): December 30, 2026
• Study Completion (Estimated): January 10, 2027
• Last Updated: January 12, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)