Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.

NCT07329751 | Not Yet Recruiting DMC

• 1 other identifier: Jia Huang
• Study Type: interventional
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal and spatial coding characteristics of frontotemporal network. Combined with EEG ( rsEEG, ERP ), nuclear magnetic resonance examination and near-infrared imaging system examination to explore its effect on brain electrophysiological activity. So as to promote the modernization of traditional Chinese medicine rehabilitation treatment technology and the popularization and application of speech rehabilitation treatment technology.

Conditions

Aphasia

Keywords

aphasia; stroke; pentatonic scales of chinese medicine

Outcome Measures

Primary Outcomes (2)

• Semantic Fluency Test

  The semantic fluency test requires subjects to say as many words related to a given semantic category as possible within 60 seconds, such as furniture, occupation, etc. The more words they say, the better the surface semantic fluency.

  Baseline and Week 4 post-intervention

• Speech fluency test

  Verbal Fluency Test: Participants are required to produce as many words as possible within 60 seconds that belong to a specified phonetic category, such as words beginning with "yi". A higher number of words indicates greater apparent verbal fluency

  Baseline and Week 4 post-intervention

Secondary Outcomes (4)

• Boston Diagnostic Aphasia Examination，BDAE

  Baseline and Week 4 post-intervention

• Minimum Mental State Examination

  Baseline and Week 4 post-intervention

• Western Aphasia Battery，WAB

  Baseline and Week 4 post-intervention

• Chinese Functional Communication Profile, CFCP

  Baseline and Week 4 post-intervention

Study Arms (3)

Experimental Group for Traditional Chinese Medicine Pentatonic Sound Therapy

EXPERIMENTAL

Therapeutic Protocol for 'Five-Tone' Therapy Based on Melodic Intonation Training Model: Subjects undergo syndrome differentiation and treatment, with corresponding 'Five-Tone' melodies selected for active training based on the melodic intonation intervention model. Intervention duration: All eligible participants in this study received four weeks of treatment, administered once daily for 40 minutes, five days per week.

Other: Traditional Chinese Medicine Five-Tone Therapy

Melodic Intonation Therapy Treatment Group

ACTIVE COMPARATOR

Melodic intonation training. Intervention duration: All eligible participants enrolled in this study received treatment for 4 weeks, once daily for 40 minutes, with sessions conducted 5 days per week.

Other: Melodic Intonation Training

Conventional control group

ACTIVE COMPARATOR

① Rehabilitation training: Physicians conduct limb movement and speech rehabilitation training for participants in accordance with the Clinical Evidence-Based Practice Guidelines for Integrated Traditional and Western Medicine Rehabilitation of Stroke (2024 Edition). ② Conventional Medical Management: Standard foundational treatment is administered to enrolled subjects in accordance with the National Health Commission's Guidelines for the Prevention and Treatment of Cerebrovascular Diseases (2024 Edition). This encompasses: management of underlying causes, blood pressure control, antiplatelet therapy, anticoagulant therapy, and regulation of blood glucose and lipid levels. ③ Health Education: Health education is provided to subjects to raise awareness of the severe risks associated with stroke and the available rehabilitation interventions.

Other: Standard speech therapy; Routine medical treatment; Health education

Interventions

Traditional Chinese Medicine Five-Tone Therapy OTHER

Therapeutic Protocol for 'Five-Tone' Therapy Based on Melodic Intonation Training Model: Subjects undergo syndrome differentiation and treatment, with corresponding 'Five-Tone' melodies selected. Based on the melodic intonation training model, active training is conducted through melodic intervention measures. ① Rehabilitation training② Conventional Medical Management.③ Health Education:

Experimental Group for Traditional Chinese Medicine Pentatonic Sound Therapy

Melodic Intonation Training OTHER

All eligible participants enrolled in the study received four weeks of melodic intonation therapy, administered once daily for 40 minutes, five days per week.① Rehabilitation training② Conventional Medical Management.③ Health Education:

Melodic Intonation Therapy Treatment Group

Standard speech therapy; Routine medical treatment; Health education OTHER

① Rehabilitation training: Physicians conduct limb movement and speech rehabilitation training for participants in accordance with the Clinical Evidence-Based Practice Guidelines for Integrated Traditional and Western Medicine Rehabilitation of Stroke (2024 Edition). ② Conventional Medical Management: Standard foundational treatment is administered to enrolled subjects in accordance with the National Health Commission's Guidelines for the Prevention and Treatment of Cerebrovascular Diseases (2024 Edition). This encompasses: management of underlying causes, blood pressure control, antiplatelet therapy, anticoagulant therapy, and regulation of blood glucose and lipid levels. ③ Health Education: Health education is provided to subjects to raise awareness of the severe risks associated with stroke and the available rehabilitation interventions.

Conventional control group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 70 years
• Right-handed
• Native Chinese speakers
• Clinical diagnosis of post-stroke aphasia caused by ischemic stroke, confirmed by CT or MRI
• Diagnosis of non-fluent aphasia based on the Western Aphasia Battery (WAB), with BDAE severity rating of 1-5
• Time since stroke onset ≥ 2 weeks
• Stable vital signs, clear consciousness, and no severe cognitive impairment
• Ability to understand the study procedures and provide written informed consent (or consent provided by a legally authorized representative)

You may not qualify if:

• History of aphasia or neurological disease not caused by stroke (e.g., traumatic brain injury, brain tumor, neurodegenerative diseases)
• Severe visual or auditory impairments that would interfere with task performance
• Severe cognitive impairment or disorders of consciousness preventing cooperation with language assessment or intervention
• Severe dysarthria or apraxia of speech that precludes valid language assessment
• History of epilepsy or other severe neurological conditions
• Severe systemic diseases (e.g., severe cardiopulmonary dysfunction, renal failure, hepatic failure, malignancy)
• Psychiatric disorders (e.g., schizophrenia, severe depression, or other major psychiatric illnesses)
• Contraindications to MRI or fNIRS assessment (e.g., metallic implants, severe claustrophobia)

Sponsors & Collaborators

• Fujian University of Traditional Chinese Medicine: lead

MeSH Terms

Conditions

Aphasia; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Jia Huang, Doctor

CONTACT

+8659188529125; jasmine1874@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 28, 2025
• First Posted: January 9, 2026
• Study Start: December 31, 2025
• Primary Completion (Estimated): September 30, 2027
• Study Completion (Estimated): September 30, 2028
• Last Updated: January 21, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share