Thyroid and Adrenal Disorders in ICU

NCT07245550 | Not Yet Recruiting

• 1 other identifier: TAICU
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

A dysregulated host response to infection results in organ failure and sepsis, a potentially fatal illness. Sepsis killed about 11 million people worldwide in 2017 and had a death rate close to 20 %

Conditions

Septic Shock

Keywords

septic shock

Outcome Measures

Primary Outcomes (1)

• serum Thyroid and adrenal hormones levels

  measurement of thyroid and adrenal hormones (TSH-FT3-FT4 - cortisol level ) will be measured by ELLISA technique in septic shock patients at ICU.

  24 hours

Study Arms (1)

Patients with septic shock in the ICU

Blood sampling for thyroid and adrenal hormones

Diagnostic Test: Blood sampling

Interventions

Blood sampling DIAGNOSTIC_TEST

Blood sampling for the hormones

Patients with septic shock in the ICU

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with septic shock admitted at intensive care unit and their age is above 18 years old

You may qualify if:

• All Patients who match the diagnostic criteria for sepsis/septic shock as stated
• admitted in ICU

You may not qualify if:

• Patients refuse to be enrolled in the study
• Patients with previous endocrinal disorders.
• Patients receiving corticosteroid or thyroid hormonal therapy.
• Pregnancy or lactation.
• Previous endocrinal gland surgery.
• Individuals with pacing rhythms, bundle branch blocks (QRS interval \>120 ms),

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Radwa mahmoud

Asyut, Egypt

Location

MeSH Terms

Conditions

Shock, Septic

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Radwa m elsayed, MB

  assuit university hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Radwa M Elsayed, MB

CONTACT

01001673731; Radwaamahmoud11@gmail.com

Mohamed F Adawy, MB

CONTACT

01001244126; DR-m.faisal85m@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: September 26, 2025
• First Posted: November 24, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 24, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)