NCT07319702

Brief Summary

The goal of this clinical trial is to evaluate the clinical effectiveness of proprioceptive neuromuscular facilitation (PNF) combined with spiral muscle chain training in improving spinal function and posture in adolescents aged 13 to 18 years with spinal curvature abnormalities. The main questions it aims to answer are: Does exercise-based intervention improve trunk inclination angle, kyphotic angle, and body balance parameters in adolescents with spinal curvature abnormalities? Does the combined intervention improve spinal mobility and paraspinal muscle endurance compared with single-intervention approaches? Does the combined intervention lead to favorable changes in surface electromyography (sEMG) indicators of the paraspinal muscles? Researchers will compare a PNF therapy group, a spiral muscle chain training group, and a combined PNF plus spiral muscle chain training group to assess differences in trunk inclination angle, kyphotic angle, spinal mobility, paraspinal muscle endurance, and neuromuscular activation outcomes. Body mass index, fat-to-muscle ratio, and other body-composition-related indicators will be analyzed as exploratory post hoc outcomes. Participants will: Be assigned to one of three intervention groups: PNF therapy alone, spiral muscle chain training alone, or combined PNF plus spiral muscle chain training. Participate in supervised exercise training sessions three times per week for 12 weeks. Undergo pre- and post-intervention assessments, including body composition testing, electronic spinal measurements, and surface electromyography testing.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
189

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 5, 2024

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2024

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

December 20, 2025

Completed
17 days until next milestone

First Posted

Study publicly available on registry

January 6, 2026

Completed
Last Updated

May 14, 2026

Status Verified

May 1, 2026

Enrollment Period

10 months

First QC Date

December 20, 2025

Last Update Submit

May 12, 2026

Conditions

Keywords

Adolescent Idiopathic ScoliosisProprioceptive Neuromuscular FacilitationSpiral Muscle Chain TrainingExercise TherapyRehabilitationSpinal Curvature Abnormalities

Outcome Measures

Primary Outcomes (3)

  • Change in Trunk Tilt Angle (ATI)

    Trunk tilt angle (Angle of Trunk Rotation, ATI) measured using an electronic spine assessment device to evaluate changes in spinal asymmetry and trunk alignment.

    Baseline and after 12 weeks of intervention

  • Change in Kyphotic Angle (KA)

    Kyphotic angle will be measured using an electronic spinal assessment device to evaluate changes in sagittal spinal curvature.

    Baseline and after 12 weeks of intervention

  • Change in Body Balance Parameters

    Body balance parameters assessed by electronic spine measurement, including head lateral deviation, shoulder asymmetry, and pelvic tilt.

    Baseline and after 12 weeks of intervention

Secondary Outcomes (6)

  • Change in Body Mass Index (BMI)

    Baseline and after 12 weeks of intervention

  • Change in Fat-to-Muscle Ratio (FMR)

    Baseline and after 12 weeks of intervention

  • Change in Spinal Mobility

    Baseline and after 12 weeks of intervention

  • Change in Surface Electromyography Parameters

    Baseline and after 12 weeks of intervention

  • Change in Trunk Muscle Activation Patterns

    Baseline and after 12 weeks of intervention

  • +1 more secondary outcomes

Study Arms (3)

Proprioceptive Neuromuscular Facilitation (PNF) Therapy

EXPERIMENTAL

Participants receive proprioceptive neuromuscular facilitation (PNF) therapy as an exercise intervention for abnormal spinal curvature. Training is conducted 3 times per week (every other day) for 12 weeks. The PNF protocol includes resisted scapular-pelvic patterns, cervical flexion/extension, trunk chopping/lifting patterns, bilateral upper-limb patterns, and bridge exercises (per PNF schedule).

Behavioral: Proprioceptive Neuromuscular Facilitation (PNF) Therapy

Spiral Muscle Chain (SPS) Training

EXPERIMENTAL

Participants receive spiral stabilizing muscle chain (SPS) training as an exercise intervention for abnormal spinal curvature. Training is conducted 3 times per week (every other day) for 12 weeks. The SPS program follows the SPS training schedule (Training 1A-6A, 7C-10C, and stretching component), with planned repetitions/sets and practice time as listed in the protocol schedule.

Behavioral: Spiral Muscle Chain (SPS) Training

Combined Exercise Therapy

EXPERIMENTAL

Participants receive a combined program consisting of PNF therapy plus SPS spiral muscle chain training as an exercise intervention for abnormal spinal curvature. Training is conducted 3 times per week (every other day) for 12 weeks.

Behavioral: Combined Exercise Therapy

Interventions

Spiral muscle chain (SPS) training is applied as an exercise-based intervention aimed at improving spinal alignment, postural control, and neuromuscular coordination in children with adolescent idiopathic scoliosis. The SPS program consists of spiral stabilization exercises performed with elastic resistance, body positioning control, and stretching components according to a standardized training protocol. Training sessions are supervised and conducted three times per week (every other day) for 12 weeks.

Also known as: Spiral Stabilization Training
Spiral Muscle Chain (SPS) Training

The combined intervention integrates proprioceptive neuromuscular facilitation (PNF) therapy and spiral muscle chain (SPS) training as a comprehensive exercise program for children with adolescent idiopathic scoliosis. Participants perform both PNF and SPS exercise components within each training cycle to target spinal alignment, muscle endurance, and neuromuscular activation. Training sessions are supervised and conducted three times per week (every other day) for 12 weeks.

Combined Exercise Therapy

Proprioceptive neuromuscular facilitation (PNF) therapy is used as an exercise-based intervention to address abnormal spinal curvature in children with adolescent idiopathic scoliosis. The PNF program includes resisted scapular-pelvic patterns, cervical flexion and extension, trunk diagonal patterns (chopping and lifting), bilateral upper-limb diagonal patterns, and bridge exercises. Training sessions are supervised and conducted three times per week (every other day) for 12 weeks.

Also known as: Proprioceptive Neuromuscular Facilitation
Proprioceptive Neuromuscular Facilitation (PNF) Therapy

Eligibility Criteria

Age13 Years - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Aged 13 to 18 years
  • Newly diagnosed with no prior treatment and meeting the diagnostic criteria for spinal curvature abnormalities
  • Scoliosis or coronal spinal curvature abnormality determined by poor posture and angle of trunk inclination or angle of trunk rotation of 5° or greater
  • Anterior-posterior spinal curvature abnormality determined by poor posture or abnormal spinal side-view assessment, including kyphotic angle less than 20° or greater than 40°
  • No prior brace treatment
  • No history of spinal surgery
  • Able to complete proprioceptive neuromuscular facilitation therapy, spiral muscle chain training, or combined exercise training as required
  • Written informed consent obtained from participants and their parents or legal guardians

You may not qualify if:

  • Menstruating females at the time of assessment
  • Metal implants
  • History of brace use or prior treatment for spinal curvature abnormalities
  • Severe scoliosis, defined as angle of trunk inclination or angle of trunk rotation greater than 13°
  • Congenital spinal curvature abnormality
  • Neuromuscular disorders
  • Respiratory dysfunction
  • Any contraindication to exercise
  • Any trauma within the previous 6 months
  • Any accompanying neurological, rheumatological, or mental health problems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Affiliated High School of Nanjing Normal University

Nanjing, Jiangsu, 210023, China

Location

Related Publications (3)

  • Xu Y, Feng M, Wu R, Wang Y, Yang Z, Wang Z, Kang Z, Xie L, Liu H. Effect of adding proprioceptive neuromuscular facilitation to conventional physiotherapy on scapular balance and shoulder proprioception in adolescents with idiopathic scoliosis: a randomised controlled trial protocol. BMJ Open. 2025 Nov 19;15(11):e106848. doi: 10.1136/bmjopen-2025-106848.

  • Nechvatal P, Hitrik T, Kendrova LD, Macej M. Comparison of the effect of the McKenzie method and spiral stabilization in patients with low back pain: A prospective, randomized clinical trial. J Back Musculoskelet Rehabil. 2022;35(3):641-647. doi: 10.3233/BMR-210055.

  • Maruyama T, Kitagawa T, Takeshita K, Mochizuki K, Nakamura K. Conservative treatment for adolescent idiopathic scoliosis: can it reduce the incidence of surgical treatment? Pediatr Rehabil. 2003 Jul-Dec;6(3-4):215-9. doi: 10.1080/13638490310001642748.

MeSH Terms

Conditions

Kyphosis

Interventions

Muscle Stretching ExercisesTherapeutics

Condition Hierarchy (Ancestors)

Spinal CurvaturesSpinal DiseasesBone DiseasesMusculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CarePhysical Therapy ModalitiesExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
PhD Candidate

Study Record Dates

First Submitted

December 20, 2025

First Posted

January 6, 2026

Study Start

March 5, 2024

Primary Completion

December 30, 2024

Study Completion

December 30, 2024

Last Updated

May 14, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Individual participant data (IPD) will not be shared because the study involves minors, and the data include sensitive health information related to spinal posture and neuromuscular function. According to the approved ethics protocol, strict measures are required to protect participants' privacy and confidentiality. Although all data are de-identified, sharing IPD may still pose a potential risk of re-identification. Therefore, IPD will not be made publicly available in order to ensure compliance with ethical requirements and data protection regulations.

Locations