"Facially Driven Digital Full-Mouth Rehabilitation"

NCT07314034 | Recruiting

• 1 other identifier: ADMNF-0051
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Participants with bite difficulties, smile dissatisfaction, and missing mandibular molars was rehabilitated using a fully digital, facially driven workflow. Integration of intraoral, facial, and CBCT data guided esthetic design, occlusion, and implant planning, resulting in precise alignment, functional occlusion, and esthetic restoration with veneers, zirconia crowns, TAD-assisted molar intrusion, and guided implants.

Conditions

Malocclusion

Outcome Measures

Primary Outcomes (1)

• Implant Stability

  Clinical assessment: Absence of implant mobility assessed manually and using opposing instrument pressure. Radiographic assessment: Periapical radiographs using the paralleling technique to evaluate peri-implant bone levels. Success criteria: No progressive peri-implant radiolucency and marginal bone loss ≤ 1.5 mm during the first year, in accordance with Albrektsson et al. success criteria.

  12 months post-treatment

Interventions

Facially Driven, Fully Digital Full-Mouth Rehabilitation with Guided Implant Placement, TAD-Assisted Molar Intrusion, and Restorative Crowns/Veneers DEVICE

Participants will receive full-mouth dental rehabilitation using advanced digital planning. Scans of the teeth, face, and jaw will guide treatment, which may include tooth movement with temporary devices, guided implant placement, and placement of custom veneers and crowns. This approach aims to restore bite function, improve smile esthetics, and ensure accurate, comfortable, and durable results.

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 20-45 years with partial or complete edentulism, bite dysfunction, or esthetic concerns requiring full-mouth rehabilitation. Participants must be medically fit for implant and minor orthodontic procedures, have adequate bone for implant placement or be candidates for TAD-assisted tooth movement, and be willing to undergo treatment using a fully digital, facially guided workflow. Both male and female patients capable of providing informed consent and complying with follow-up visits are eligible.

You may qualify if:

• Adults aged 20-45 years with partial or complete edentulism requiring full-mouth rehabilitation.
• Patients with bite dysfunction, malocclusion, or esthetic concerns suitable for digital workflow treatment.
• Adequate bone volume for implant placement or candidates for TAD-assisted tooth movement.
• Willingness to undergo treatment using a fully digital, facially guided workflow and comply with follow-up visits.
• Ability to provide informed consent.

You may not qualify if:

• Systemic conditions contraindicating implant or surgical procedures (e.g., uncontrolled diabetes, immunosuppression).
• Active oral infections or untreated periodontal disease.
• Heavy smokers (\>10 cigarettes/day) or substance abuse.
• History of head and neck radiation therapy or bisphosphonate use.
• Pregnancy or breastfeeding.
• Inability to comply with treatment or follow-up protocol.

Sponsors & Collaborators

• Menoufia University: lead
• Mansoura University: collaborator

Study Sites (1)

Faculty of Dentistry

Shibīn al Kawm, Menoufia, Egypt

RECRUITING

MeSH Terms

Conditions

Malocclusion

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Mohammed A. El-Sawy, PhD

CONTACT

00201061314522; Dr_sawy@windowslive.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor and principle investigator

Study Record Dates

• First Submitted: December 2, 2025
• First Posted: January 2, 2026
• Study Start: June 1, 2024
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: January 2, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)