NCT07312552|Recruiting
Association of Periodontal Status and Smoking With Salivary Inflammasome Markers
The Impact of Periodontal Status and Smoking on Salivary Inflammasome Levels: A Cross-Sectional Study
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The Impact of Periodontal Status and Smoking on Salivary Inflammasome Levels: A Cross-Sectional Study
Sponsor study identifier
observational
116
1 country
1
Study Start
December 23, 2025
Actual (reported)Primary Completion
June 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 16, 2025
Actual (reported)December 23, 2025
Actual (reported)December 31, 2025
Actual (reported)June 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Clinical attachment level (mm)
Clinical attachment level (CAL) is a more reliable indicator of periodontal support around a tooth than probing depth alone, as it is measured from a fixed anatomical landmark-the cementoenamel junction (CEJ)-which remains constant over time. Calculating CAL requires two measurements: the distance from the gingival margin to the CEJ and the probing depth. In cases of gingival recession, CAL is calculated by adding the probing depth to the distance from the gingival margin to the CEJ. In cases of gingival overgrowth, CAL is determined by subtracting the distance from the gingival margin to the CEJ from the probing depth.
Baseline
Probing pocket depth
Measurement of the depth of a sulcus or periodontal pocket determined by measuring distance from a gingival margin to the base of the sulcus or pocket with a calibrated periodontal probe.
Baseline
Bleeding on probing
The number obtained by dividing the sum of the positive areas by the sum of the examined areas is multiplied by 100 and the value obtained is expressed as the percentage of bleeding at probing (BOP%).
Baseline
Plaque percentage
Baseline
Periodontal inflammatory surface area (PISA)
Baseline
Salivary interleukin-10 (IL-10) levels
Baseline
Salivary interleukin-1beta (IL-1β) levels
Baseline
Salivary NOD-like receptor family, pyrin domain containing 3 (NLRP-3) levels
Baseline
Healthy individuals (control (C))
Smokers with healthy periodontium (S-C)
Nonsmokers with Stage III/IV periodontitis (P)
Smokers with Stage III/IV periodontitis (S-P)
With periodontal evaluation, plaque percentage, probing pocket depth, percentage of bleeding on probing, clinical attachment level, number of teeth, periodontal inflammatory surface area (PISA) parameters are recorded.
The study will consist of four groups: Group 1: healthy individuals (control (C)), Group 2: smokers with healthy periodontium (S-C), Group 3: nonsmokers with Stage III/IV periodontitis (P), Group 4: smokers with Stage III/IV periodontitis (S-P)
Uskudar University, Faculty of Dentistry
Istanbul, Turkey (Türkiye)
Unstimulated whole saliva samples will be collected from all participants. Samples will be stored at -80°C until analysis.The stored saliva samples will be used exclusively for the measurement of biomarker levels via ELISA. No DNA extraction or genetic analyses will be conducted.
Kubra KARADURAN
Uskudar University
First Submitted
December 16, 2025
First Posted
December 31, 2025
Study Start
December 23, 2025
Actual (reported)Primary Completion
June 2026
Estimated (date passed)Salivary Gasdermin E and Granzyme B Levels in Patients With Periodontitis
Levels of salivary NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β), and interleukin-10 (IL-10) will be determined using an enzyme-linked immunosorbent assay (ELISA).
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
January 21, 2026
Record last verified: 2026-01
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