NCT07312058

Brief Summary

Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment. However, few studies have analyzed the long-term reproductive outcomes of these interventions, nor how patients ultimately use or do not use the FP options once in remission. This project aims to better understand the effectiveness, utilization, and psychological impacts of these strategies. This work is part of an effort to understand and evaluate fertility preservation practices implemented for women of reproductive age undergoing cancer treatment at the Amiens-Picardie University Hospital (CHU). Its objective is to document patient pathways, clinical decisions, techniques employed, and reproductive outcomes observed after remission, in order to identify potential areas for improvement in the support and follow-up of these patients, thereby enhancing the overall quality and coordination of care. This work is conducted alongside the development of a fertility observatory at the Department of Medicine and Reproductive Biology, CHU Amiens-Picardie.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
102

participants targeted

Target at P50-P75 for all trials

Timeline
8mo left

Started Dec 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress37%
Dec 2025Jan 2027

First Submitted

Initial submission to the registry

November 17, 2025

Completed
1 month until next milestone

Study Start

First participant enrolled

December 17, 2025

Completed
14 days until next milestone

First Posted

Study publicly available on registry

December 31, 2025

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

January 16, 2026

Status Verified

January 1, 2026

Enrollment Period

1 year

First QC Date

November 17, 2025

Last Update Submit

January 15, 2026

Conditions

Fertility PreservationCancer RemissionReproductive HealthOncologyFertility CounselingAssisted Reproductive TechnologyPsychological ImpactFertility ObservatoryPatient Follow-upFemale Cancer SurvivorsFertility Preservation TechniquesLive Birth RateReproductive Outcomes

Keywords

Fertility preservationCancer remissionReproductive outcomesReproductive healthOncologyFertility counselingAssisted reproductive technologyPsychological impactFertility observatoryPatient follow-upFemale cancer survivorsFertility preservation techniquesLive birth rate

Outcome Measures

Primary Outcomes (1)

  • Occurrence of an identifiable reproductive outcome

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

    1 year

Secondary Outcomes (11)

  • Type of fertility preservation method performed

    1 year

  • Time interval (in months) between diagnosis and fertility preservation

    1 year

  • Correlation between Age and occurance of an identifiable reproductive outcome

    1 year

  • Time interval (in months) between fertility preservation and initiation of potentially gonadotoxic treatment

    1 year

  • Number of type of cancer associated with identifiable reproductive outcome

    1 year

  • +6 more secondary outcomes

Eligibility Criteria

Age18 Years - 47 Years
Sexall(Gender-based eligibility)
Gender Eligibility Details* Women * Aged between 18 and 47 years * Diagnosed with cancer or hematological disorders requiring potentially gonadotoxic treatment
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Patients are recruited during follow-up consultations as part of the establishment of a fertility observatory within the Department of Medicine and Reproductive Biology at CHU Amiens Picardie

You may qualify if:

  • Women
  • Aged between 18 and 47 years
  • Diagnosed with cancer or hematological disorders requiring potentially gonadotoxic treatment
  • Having undergone a medical fertility preservation consultation
  • Followed at Amiens Picardie University Hospital (CHU Amiens Picardie) in the department of Reproductive Medicine
  • Currently in remission
  • Having expressed non-opposition to participation in the study

You may not qualify if:

  • Absence of remission
  • Patients deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curators)
  • Decline to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU Amiens Picardie

Amiens, France

RECRUITING

MeSH Terms

Conditions

Neoplasms

Central Study Contacts

CABRY-GOUBET Rosalie, Pr

CONTACT

33+3 22 08 80 00cabry.rosalie@chu-amiens.fr

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 17, 2025

First Posted

December 31, 2025

Study Start

December 17, 2025

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Last Updated

January 16, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

FR(1)