Cohort Study on Medical Students' Mental Health

NCT07305701 | Recruiting

• 1 other identifier: CHUO-2025-10
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to identify risk factors for depression among medical students by comparing them to students who completed their first year but did not enter the medical program (students not accepted into the second year of medical school). Major Depressive Disorder (MDD) will be assessed using a validated tool: the Composite International Diagnostic Interview Short-Form (CIDI-SF). This a prospective, longitudinal, cohort study. The plan is to inform each new cohort of students at the Orléans University Hospital medical school for 10 years. It is estimated that 5,000 to 10,000 students will be able to participate in the study. A link to access the study questionnaire will be sent to students by email via the registrar's office, with one email per week for four weeks. The email will contain a link to a web page where the questionnaire can be completed. The questionnaire will be available online on computers or smartphones for six weeks: from mid-October to the end of November. The questionnaire will be completed each year for the duration of the study or until the student completes their studies. Duration of the inclusion period: 10 years Duration of participation for each participant: maximum 12 years Total duration of the study: 22 years As the cohort progresses, longitudinal analyses may be conducted to study the evolution of various disorders over time, adjusting for known confounding factors. Following the initial analyses of this study, a new interventional study will be set up to identify students at risk and offer them appropriate care.

Conditions

Generalized Anxiety Disorder; Alcoholism; Marijuana Abuse; Loneliness; Major Depressive Disorder; Suicidal Ideation

Keywords

Students; Medical students; depression; epidemiology

Outcome Measures

Primary Outcomes (1)

• Measure Major Depressive Disorder prevalence

  Measure of the 12-month Major Depressive Disorder prevalence by the Composite International Diagnostic Interview Short-Form (CIDI-SF).

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

Secondary Outcomes (8)

• Measure prevalence of psychiatric disorders

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

• Identify risk and protective factors for psychiatric disorders

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

• Measure Major Depressive Disorder prevalence by year

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

• Measure the prevalence of healthcare use and non-use

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

• Identify risk factors for non-use of healthcare

  Students fulfil the questionnaire on line once a year from enrollment until students complete their studies.

Study Arms (2)

Medical students

Medical students: students who succeed to integrate medical school after the selection at the end of the first year of health studies.

Other: Questionnaire

Non medical students

Non medical students: students who fail to integrate medical school after the selection at the end of the first year of health studies.

Other: Questionnaire

Interventions

Questionnaire OTHER

Questionnaire to be completed once a year

Medical students; Non medical students

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All students who were enrolled in their first year of health studies at the University of Orléans

You may qualify if:

• Students who have been enrolled in first year of health studies at the University of Orléans
• Aged 18 or over

You may not qualify if:

• Does not speak French
• Person under legal guardianship
• Person deprived of liberty
• Person under guardianship or trusteeship

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

Centre Hospitalier Universitaire d'Orléans

Orléans, Loiret, 45067, France

RECRUITING

Related Publications (12)

• Husky MM, Leon C, du Roscoat E, Vasiliadis HM. Prevalence of suicidal thoughts and behaviors among young adults between 2000 and 2021: Results from six national representative surveys in France. Psychiatry Res. 2024 Mar;333:115763. doi: 10.1016/j.psychres.2024.115763. Epub 2024 Feb 1.

  PMID: 38325160 BACKGROUND

• Frajerman A, Chevance A, Chaumette B, Morvan Y. Prevalence and factors associated with depression and suicidal ideation among French students in 2016: A national study. Psychiatry Res. 2023 Aug;326:115263. doi: 10.1016/j.psychres.2023.115263. Epub 2023 May 30.

  PMID: 37295352 BACKGROUND

• Frajerman A, Rolland F, Hadouiri N, Haas-Jordache A, Gouy E, Mathieu L, Goulard A, Leon C, Morvan Y. Depression and suicidal thoughts in medical students and the general population: A comparison from 2 national studies. Gen Hosp Psychiatry. 2024 Sep-Oct;90:204-205. doi: 10.1016/j.genhosppsych.2024.07.002. Epub 2024 Jul 4. No abstract available.

  PMID: 38997936 BACKGROUND

• Rolland F, Hadouiri N, Haas-Jordache A, Gouy E, Mathieu L, Goulard A, Morvan Y, Frajerman A. Mental health and working conditions among French medical students: A nationwide study. J Affect Disord. 2022 Jun 1;306:124-130. doi: 10.1016/j.jad.2022.03.001. Epub 2022 Mar 8.

  PMID: 35276314 BACKGROUND

• Vergeron L, Morvan Y, Hadouiri N, Haas-Jordache A, Gouy E, Mathieu L, Goulard A, Rolland F, Frajerman A. Use of service and treatment adequacy in medical students and residents suffering from depression in France: A nationwide study. Psychiatry Res. 2024 Sep;339:115975. doi: 10.1016/j.psychres.2024.115975. Epub 2024 May 31.

  PMID: 38875916 BACKGROUND

• Frajerman A. [Which interventions improve the well-being of medical students? A review of the literature]. Encephale. 2020 Feb;46(1):55-64. doi: 10.1016/j.encep.2019.09.004. Epub 2019 Nov 22. French.

  PMID: 31767254 BACKGROUND

• Gosling CJ, Colle R, Cartigny A, Jollant F, Corruble E, Frajerman A. Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales. Psychol Med. 2024 Oct 31;54(14):1-7. doi: 10.1017/S0033291724002083. Online ahead of print.

  PMID: 39479755 BACKGROUND

• Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092.

  PMID: 16717171 BACKGROUND

• Garcia FD, Grigioni S, Chelali S, Meyrignac G, Thibaut F, Dechelotte P. Validation of the French version of SCOFF questionnaire for screening of eating disorders among adults. World J Biol Psychiatry. 2010 Oct;11(7):888-93. doi: 10.3109/15622975.2010.483251.

  PMID: 20509759 BACKGROUND

• Gache P, Michaud P, Landry U, Accietto C, Arfaoui S, Wenger O, Daeppen JB. The Alcohol Use Disorders Identification Test (AUDIT) as a screening tool for excessive drinking in primary care: reliability and validity of a French version. Alcohol Clin Exp Res. 2005 Nov;29(11):2001-7. doi: 10.1097/01.alc.0000187034.58955.64.

  PMID: 16340457 BACKGROUND

• Luquiens A, Berger-Viergat A, Larrieu A, Artigaud L, Fener C, Adamson S, Laprevote V, Rolland B. Validation of the French version of the Cannabis Use Disorder Identification Test-Revised and comparison with the Cannabis Abuse Screening Test for screening cannabis use disorder in a psychiatric sample. Drug Alcohol Rev. 2021 Nov;40(7):1334-1339. doi: 10.1111/dar.13298. Epub 2021 Apr 14.

  PMID: 33855757 BACKGROUND

• Simon N, Verdoux H. [Impact of education program and clinical posting in psychiatry on medical students' stigmatizing attitudes towards psychiatry and psychiatric disorders]. Encephale. 2018 Sep;44(4):329-336. doi: 10.1016/j.encep.2017.05.003. Epub 2017 Jun 9. French.

  PMID: 28606624 BACKGROUND

MeSH Terms

Conditions

Depressive Disorder, Major; Generalized Anxiety Disorder; Suicidal Ideation; Alcoholism; Marijuana Abuse; Depression

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Anxiety Disorders; Suicide; Self-Injurious Behavior; Behavioral Symptoms; Behavior; Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Jasmina MALLET, MD-PhD

  CHOrléans

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jasmina MALLET, MD-PhD

CONTACT

0238229795; jasmina.mallet@chu-orleans.fr

Fanny LOUAT

CONTACT

0238744295; fanny.louat@chu-orleans.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: December 26, 2025
• Study Start: October 22, 2025
• Primary Completion (Estimated): October 31, 2047
• Study Completion (Estimated): October 31, 2047
• Last Updated: December 31, 2025

Record last verified: 2025-12

Locations

FR (1)