Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience

NCT07291882 | Completed

• 1 other identifier: Serum Hyperbilirubinemia
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low. Because testing is rapid, inexpensive, and universally available, integration into local diagnostic pathways is feasible.

Conditions

Appendicitis, Surgery

Outcome Measures

Primary Outcomes (1)

• measurement of serum total bilirubin in each case of appendicitis to clarify the relationship between serum hyperbilirubinemia and complicated appendicitis

  between September 2024 and August 2025

Study Arms (2)

Simple appendicitis ( group A)

Patients where no perforation, gangrene, or other complications were found during surgery.

Procedure: Appendectomy

Complicated appendicitis (group B)

• Complicated appendicitis group (B): Patients who presented with perforation or gangrene, confirmed via operative findings and histopathological examination. Total bilirubin levels was measured preoperatively as part of the routine laboratory workup.

Procedure: Appendectomy

Interventions

Appendectomy PROCEDURE

Total bilirubin levels was measured preoperatively as part of the routine laboratory workup. Appendectomy done for all patients followed by histopathological evaluation of the excised appendix.

Complicated appendicitis (group B); Simple appendicitis ( group A)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients presenting with acute appendicitis at the Minia university hospital

You may qualify if:

• All patients presented with right iliac fossa pain diagnosed clinically as acute appendicitis and had undergone appendectomy

You may not qualify if:

• patients with past history of jaundice
• patients with history of hyperbilirubinemia hemolytic disease
• positive hepatitis viruses
• cholelithiasis
• acquired or congenital biliary disease
• cancer of the hepatobiliary system

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Minia university

Minya, Egypt

Location

MeSH Terms

Conditions

Appendicitis

Interventions

Appendectomy

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Intervention Hierarchy (Ancestors)

Digestive System Surgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director and lecturer of general surgery

Study Record Dates

• First Submitted: December 6, 2025
• First Posted: December 18, 2025
• Study Start: September 1, 2024
• Primary Completion: September 10, 2024
• Study Completion: August 20, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)