Post-Endodontic Pain According to Menstrual Cycle Phases

NCT07291518 | Completed

• 2 other identifiers: MCOBAN-ENDO20252023/184 (Ethics Approval)
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate whether the phase of the menstrual cycle affects pain after root canal treatment. A total of 99 patients (72 females and 27 males) who needed root canal treatment in lower molar teeth were included. Female participants were grouped according to their menstrual cycle phase: menstrual, proliferative, and secretory. All patients received the same endodontic treatment procedure under local anesthesia. Postoperative pain intensity was recorded using a Visual Analog Scale (VAS) at 8 hours, 8-24 hours, 24-48 hours, and 48-72 hours after treatment. Analgesic (ibuprofen) use was also recorded. The results showed that women in the menstrual and secretory phases experienced higher pain levels than men, while pain levels in the proliferative phase were similar to those in men. The findings suggest that the menstrual cycle phase may influence short-term pain perception after root canal treatment.

Conditions

Root Canal Treatment

Keywords

Endodontic treatment; Post-endodontic pain; Pain perception; Mandibular molars; Dental pain; postoperative pain; Menstrual cycle

Outcome Measures

Primary Outcomes (1)

• Post-Endodontic Pain Intensity

  Measured using Visual Analog Scale (VAS) at 8 hours, 8-24 hours, 24-48 hours, and 48-72 hours after root canal treatment. Participants self-recorded the highest pain intensity at each time point.

  Up to 72 hours post-treatment.

Interventions

root canal treathment PROCEDURE

All participants underwent standard root canal treatment under local anesthesia and rubber dam isolation. Root canals were prepared using ProTaper Next rotary files, irrigated with 2.5% sodium hypochlorite and 17% EDTA, dried with paper points, and filled using a sealant and gutta-percha. The teeth were then restored coronally with composite resin. Postoperative pain and analgesic use were monitored for 72 hours to assess the influence of menstrual cycle phase on pain perception. This standardized procedure ensures consistency across participants and allows comparisons between menstrual phases and between male patients.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of 99 adult patients (72 females and 27 males), aged 18-50 years, requiring endodontic treatment for asymptomatic necrotic mandibular first or second molars. Female participants have regular menstrual cycles and are categorized into menstrual, proliferative, or secretory phases. Patients with systemic diseases, smoking habits, preoperative pain, parafunctional habits, teeth requiring prosthetic restoration, immature teeth, periodontal probing depth greater than 3 mm, or irregular menstrual cycles are excluded. All participants provided written informed consent prior to enrollment.

You may qualify if:

• Age 18-50 years
• Male or female patients requiring endodontic treatment of asymptomatic
• Necrotic mandibular first or second molars
• Female patients with regular menstrual cycles
• Patients who have not taken analgesics in the last 3 days
• Patients willing to provide written informed consent

You may not qualify if:

• Smoking habit
• Systemic diseases or use of systemic drugs
• Parafunctional habits such as bruxism
• Preoperative pain
• Teeth requiring prosthetic restoration
• Teeth with external or internal resorption
• Immature teeth
• Periodontal probing depth \> 3 mm
• Pregnant women
• Women with irregular menstrual cycles
• Patients who refuse to participate

Sponsors & Collaborators

• Ahter Sanal Cikman: lead

Study Sites (1)

Recep Tayyip Erdoğan Univercity

Rize, 53020, Turkey (Türkiye)

Location

Related Links

• Related Info

MeSH Terms

Conditions

Toothache; Pain, Postoperative

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Facial Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pathologic Processes

Study Officials

• Merve Çoban Öksüzer

  pamukkale univercity

  PRINCIPAL INVESTIGATOR

• Ömer Hatipoğlu

  recep tayyip erdoğan univercity

  STUDY DIRECTOR

• Fatma Pertek Hatipoğlu

  recep tayyip erdoğan univercity

  STUDY DIRECTOR

• ahter şanal çıkman

  recep tayyip erdoğan univercity

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator (PI), Assistant Professor of Endodontics

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: December 18, 2025
• Study Start: September 1, 2023
• Primary Completion: January 15, 2025
• Study Completion: January 30, 2025
• Last Updated: December 26, 2025

Record last verified: 2025-12

Locations

TU (1)