Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)

NCT07288099 | Recruiting

• 1 other identifier: E-24687260-604.01-1455240
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS). In our clinic, anesthesia for VATS is commonly provided either with target-controlled infusion (TCI) or with inhalational agents, depending on the routine practice of the anesthesiologist. No randomization or additional intervention will be performed. During the study period, patients who receive either method as part of standard care will be followed, and perioperative and postoperative data will be recorded. Awakening time, extubation time, Aldrete score progression, pain levels, and early postoperative complications will be compared between the two groups. The aim is to better understand how these widely used anesthesia techniques may influence recovery in VATS patients and to support future clinical decision-making.

Conditions

Video-assisted Thoracoscopic Surgery (VATS); Thoracic Surgery, Video Assisted; Postoperative Recovery; General Anesthesia; Anesthesia Techniques

Keywords

Video-Assisted Thoracoscopic Surgery; VATS; Thoracic Surgery; Target-Controlled Infusion; Inhalational Anesthesia; Postoperative Recovery; Extubation Time

Outcome Measures

Primary Outcomes (1)

• Extubation Time

  Time from discontinuation of anesthesia to removal of the endotracheal tube. Extubation time will be recorded routinely in the operating room as part of standard postoperative monitoring.

  Up to 30 minutes after the end of surgery

Secondary Outcomes (3)

• Awakening Time

  Up to 20 minutes after surgery

• Aldrete Score Progression

  PACU stay, up to 1 hour

• Postoperative Pain Score (NRS)

  First hour after PACU admission

Study Arms (2)

TCI Group

Patients receiving target-controlled infusion (TCI) anesthesia as part of routine clinical care during VATS procedures. No intervention is assigned by the study team.

Inhalational Anesthesia Group

Patients receiving inhalational anesthesia (e.g., sevoflurane) as part of routine clinical care during VATS procedures. No intervention is assigned by the study team.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients undergoing elective video-assisted thoracoscopic surgery (VATS) at our institution. In routine practice, anesthesia for these procedures is provided either with target-controlled infusion (TCI) or with inhalational agents, according to the preference of the attending anesthesiologist. Patients between 18 and 65 years of age who meet the clinical criteria for VATS and are able to give informed consent will be included. Individuals with significant cardiorespiratory instability, ASA IV or higher, or conditions that may interfere with postoperative assessment will not be enrolled.

You may qualify if:

• Adults aged 18 to 65 years
• Patients scheduled for elective video-assisted thoracoscopic surgery (VATS)
• ASA physical status I-III
• Able to provide informed consent
• Planned postoperative recovery in PACU and surgical ward

You may not qualify if:

• ASA IV or higher
• Hemodynamic or respiratory instability before surgery
• Known allergy or contraindication to commonly used anesthetic agents
• Neurological or psychiatric conditions that may interfere with recovery assessment
• Emergency surgeries
• Patients who decline participation

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Istanbul University Cerrahpasa Medical Faculty

Istanbul, Istanbul, Turkey (Türkiye)

RECRUITING

Central Study Contacts

mert katılmış, md

CONTACT

+905346430560; mertkatilmis97@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant, MD

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: December 17, 2025
• Study Start: January 12, 2026
• Primary Completion: June 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: March 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)