Impact of Combined Intravenous-Inhalational vs Inhalational Anesthesia on QoR-15 Recovery Scores in Gynecologic Surgery

NCT07506798 | Recruiting

• 1 other identifier: E.513181 (Application No: 473)
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of combined intravenous-inhalational anesthesia versus inhalational anesthesia alone on postoperative recovery in patients undergoing elective gynecologic surgery. A total of 100 patients, aged 18-65 years and classified as ASA I-III, scheduled for elective gynecologic procedures at Sakarya University Faculty of Medicine Training and Research Hospital, will be included. The sample size was calculated based on the primary outcome, the Quality of Recovery-15 (QoR-15) score. Patients will complete the QoR-15 questionnaire preoperatively, before knowing which anesthesia method will be applied. Postoperative QoR-15 scores will be collected on postoperative days 1 and 2, and intraoperative data will be obtained from anesthesia records. The study evaluates postoperative recovery using QoR-15 scores, covering physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery, whereas lower scores indicate impaired postoperative recovery.

Conditions

Gynecologic Surgery; Postoperative Recovery; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Postoperative recovery using QoR-15

  Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, a validated patient-reported outcome measure. The questionnaire evaluates physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery.

  Postoperative Day 1 and Postoperative Day 2

Secondary Outcomes (3)

• Postoperative pain score

  Postoperative hours 6, 12, and 24

• Postoperative nausea and vomiting (PONV) incidence

  Postoperative hours 0-24

• Length of stay in post-anesthesia care unit (PACU)

  Postoperative period (PACU stay), assessed up to 10 days

Study Arms (2)

Combined Intravenous-Inhalational Anesthesia

EXPERIMENTAL

Patients in this group will receive a combination of intravenous and inhalational anesthesia during elective gynecologic surgery. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.

Drug: Combined Intravenous-Inhalational Anesthesia

Inhalational Anesthesia Only

ACTIVE COMPARATOR

Patients in this group will receive only inhalational anesthesia during elective gynecologic surgery. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.

Drug: Inhalational Anesthesia Only

Interventions

Combined Intravenous-Inhalational Anesthesia DRUG

Patients will receive a combination of intravenous anesthetic agents and inhalational anesthetic gases during elective gynecologic surgery. The specific anesthetic drugs and doses will follow routine clinical practice. Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1 and 2.

Combined Intravenous-Inhalational Anesthesia

Inhalational Anesthesia Only DRUG

Patients will receive only inhalational anesthetic gases during elective gynecologic surgery, following routine clinical practice. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.

Inhalational Anesthesia Only

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 18-65 years
• Scheduled for elective gynecologic surgery at Sakarya University Faculty of Medicine Training and Research Hospital
• Classified as ASA I-III
• Able to understand and complete the QoR-15 questionnaire
• Provided written informed consent

You may not qualify if:

• Severe comorbidities (beyond ASA III)
• Patients with advanced neurological disease or cognitive impairment
• Known allergy to anesthetic drugs used in the study
• Classified as ASA IV-V
• Refusal to participate in the study
• Emergency or urgent surgery

Sponsors & Collaborators

• Sakarya University: lead

Study Sites (1)

Sakarya University Training and Research Hospital

Sakarya, 54290, Turkey (Türkiye)

RECRUITING

Central Study Contacts

melike kar ünlü, MD

CONTACT

905079790381; Melikekar2015@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Model Details: Patients will be randomly assigned in a parallel design to one of two groups: Combined intravenous-inhalational anesthesia group Inhalational anesthesia only group Each patient will receive only one anesthesia method during their elective gynecologic surgery. Outcomes will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1 and 2. This design allows a direct comparison of postoperative recovery between the two anesthesia methods.

Study Record Dates

• First Submitted: March 14, 2026
• First Posted: April 2, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: April 2, 2026

Record last verified: 2026-03

Locations

TU (1)