Exploring the Relationship Between Range of Motion in Knee Rehabilitation Exercises and Pain in Patellofemoral Pain Syndrome

NCT07287267 | Recruiting

• 1 other identifier: 2024-01422-01
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the relationship between knee joint range of motion and pain in patients with patellofemoral pain syndrome (PFPS). In a cross-sectional observational design, PFPS patients will perform trials involving progressively increased knee joint range of motion in three closed-chain exercises: squat, single-leg squat, and split squat. During each trial, participants will report pain levels on a 0-10 Visual Analog Scale (VAS) until either (1) achieving full depth in the respective exercise or (2) reaching a pain level of \>5 on the VAS.

Conditions

Patello Femoral Syndrome

Keywords

Patellofemoral pain syndrome; Range of motion; patellofemoral pain

Outcome Measures

Primary Outcomes (2)

• Pain (VAS)

  Pain measured 0-10 visual analog scale (VAS) reported during each trial of progressively increased range of motion during a single session.

  Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

• Range of motion

  Degrees of knee flexion measured during each trial in one single session.

  Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

Secondary Outcomes (2)

• Force

  Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

• Tegner Activity Scale (TAS)

  Baseline (Administered at the beginning of the study)

Study Arms (1)

Patellofemoral Pain Syndrome

Patients diagnosed with patellofemoral pain syndrome by health care provider.

Other: Exercise

Interventions

Exercise OTHER

Exercise with progressively increased range of motion.

Patellofemoral Pain Syndrome

Eligibility Criteria

• Age: 15 Years - 35 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

This project will include patients diagnosed with PFP (ICD-10: M22.2).

You may qualify if:

• Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
• Aged 15-35 years.
• A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.

You may not qualify if:

• Any prior injury or condition with residual symptoms that may affect the results.
• Current injury or condition affecting the performance of the test.
• Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.

Sponsors & Collaborators

• Ted Gunhamn: lead

Study Sites (1)

Linnaues University

Kalmar, Sweden

RECRUITING

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Interventions

Exercise

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD Candidate

Study Record Dates

• First Submitted: September 4, 2025
• First Posted: December 17, 2025
• Study Start: December 1, 2024
• Primary Completion: December 3, 2025
• Study Completion: April 1, 2026
• Last Updated: December 17, 2025

Record last verified: 2025-12

Locations

SE (1)