Relation Between Femoral Nerve Conduction Velocity and Its Mechanosensitivity Changes Among Patellofemoral Pain Syndrome

NCT04624542 | Unknown

• 1 other identifier: NCV for PFPS
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.to investigate the relation between NCV of femoral nerve and other dependent variables such as ( pain \& limited hip extension ROM )in patients with PFPS .
2. 2.to predict using the NCV as a method for assessment femoral nerve mechanosensitivity in those with PFPS

Conditions

Patello Femoral Syndrome

Keywords

femoral nerve conduction velocity

Outcome Measures

Primary Outcomes (1)

• the patellofemoral pain

  pain will be measured by using the Pain numeric rating scale (NRS)

  6 months

Secondary Outcomes (1)

• range of hip extension

  6 month

Study Arms (2)

group 1

Thirty individuals diagnosed with unilateral chronic PFPS from both genders and age between 18-35 years who will be referred from an orthopedic surgeon.

Device: Electromyographic device

control group

-30 healthy active individuals ranging from 18-36 yrs as a controlled group

Device: Electromyographic device

Interventions

Electromyographic device DEVICE

the EMG machine will be used to measure NCV of femoral nerve within individuals with PFPS

control group; group 1

Eligibility Criteria

• Age: 18 Years - 36 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants recruitment to this study will be conducted over 2 steps process. In the first step, all participants in the experimental group that will be referred from an orthopedic surgeon with diagnosis of unilateral PFPS to the outpatient clinic at Cairo University hospital at kasr el ainy

You may qualify if:

• Patient reporting symptoms of insidious onset and duration of at least 1 month (de Oliveira et al .,2016)
• Peri- or retropatellar pain during at least 2 of the following activities: squatting, prolonged sitting, kneeling, running, jumping and climbing stairs (Vegstein et al., 2019)
• Worst pain level in the previous month of up to 3cm on a 10cm numerical rating scale (NRS). (de Oliveira et al .,2016)
• BMI 25-30 kg/cm2 (Nouri F et al .,2019)
• Showing 2 or more positive signs on the following clinical tests:
• Clarke's sign, Waldron test, active patellar grind test, patellar compression test ,and palpation of the medial/lateral articular border of the patella.(hung et al., 2015) To be included in the control group CG, participants could not present any signs or symptoms of PFP or other musculoskeletal conditions

You may not qualify if:

• \) inflammatory process of lower limb (Lin et al., 2014 ) 2) patellar tendon or meniscus tears (hung et al., 2015) 3) bursitis and ligament tears (hung et al., 2015) 4) Those who had undergone knee surgery, oral steroids and knee injection were excluded from this study (Vegstein et al., 2019) 5) lower back dysfunction such as disc lesion , sciatica or spondylolisthesis (Lin et al., 2014 ) 6) participants that had undergone physiotherapy during the preceding 6 months (de Oliveira et al .,2016)

Sponsors & Collaborators

• Cairo University: lead

Related Publications (8)

• Fredericson M, Yoon K. Physical examination and patellofemoral pain syndrome. Am J Phys Med Rehabil. 2006 Mar;85(3):234-43. doi: 10.1097/01.phm.0000200390.67408.f0.

  PMID: 16505640 BACKGROUND

• Fredericson M, Powers CM. Practical management of patellofemoral pain. Clin J Sport Med. 2002 Jan;12(1):36-8. doi: 10.1097/00042752-200201000-00010. No abstract available.

  PMID: 11854587 BACKGROUND

• Jensen R, Kvale A, Baerheim A. Is pain in patellofemoral pain syndrome neuropathic? Clin J Pain. 2008 Jun;24(5):384-94. doi: 10.1097/AJP.0b013e3181658170.

  PMID: 18496302 BACKGROUND

• Jensen R, Hystad T, Kvale A, Baerheim A. Quantitative sensory testing of patients with long lasting Patellofemoral pain syndrome. Eur J Pain. 2007 Aug;11(6):665-76. doi: 10.1016/j.ejpain.2006.10.007. Epub 2007 Jan 3.

  PMID: 17204440 BACKGROUND

• Eliav E, Benoliel R, Tal M. Inflammation with no axonal damage of the rat saphenous nerve trunk induces ectopic discharge and mechanosensitivity in myelinated axons. Neurosci Lett. 2001 Sep 21;311(1):49-52. doi: 10.1016/s0304-3940(01)02143-7.

  PMID: 11585565 BACKGROUND

• Sanchis-Alfonso V, Rosello-Sastre E. Immunohistochemical analysis for neural markers of the lateral retinaculum in patients with isolated symptomatic patellofemoral malalignment. A neuroanatomic basis for anterior knee pain in the active young patient. Am J Sports Med. 2000 Sep-Oct;28(5):725-31. doi: 10.1177/03635465000280051801.

  PMID: 11032232 BACKGROUND

• Heintjes E, Berger MY, Bierma-Zeinstra SM, Bernsen RM, Verhaar JA, Koes BW. Exercise therapy for patellofemoral pain syndrome. Cochrane Database Syst Rev. 2003;(4):CD003472. doi: 10.1002/14651858.CD003472.

  PMID: 14583980 BACKGROUND

• Smith BE, Selfe J, Thacker D, Hendrick P, Bateman M, Moffatt F, Rathleff MS, Smith TO, Logan P. Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis. PLoS One. 2018 Jan 11;13(1):e0190892. doi: 10.1371/journal.pone.0190892. eCollection 2018.

  PMID: 29324820 RESULT

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Officials

• nabil ab abdo

  PHD faculty of physical therapy Cairo university

  STUDY DIRECTOR

Central Study Contacts

ramez fd fahim, Bachelor

CONTACT

201211553069; ramezfahim1993@gmail.com

nabil ab abdo, PHD

CONTACT

201144259011

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of orthopedic physiotherapy /faculty of physical therapy cairo university

Study Record Dates

• First Submitted: November 5, 2020
• First Posted: November 12, 2020
• Study Start: December 1, 2020
• Primary Completion: June 1, 2021
• Study Completion: August 1, 2021
• Last Updated: November 12, 2020

Record last verified: 2020-11