NCT06484101

Brief Summary

Healthy human subjects perform supramaximal exercise with venous blood samples obtained before and up to 60 minutes after the exercise bout.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
7

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 31, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 22, 2023

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 14, 2024

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

June 18, 2024

Completed
15 days until next milestone

First Posted

Study publicly available on registry

July 3, 2024

Completed
Last Updated

July 3, 2024

Status Verified

June 1, 2024

Enrollment Period

9 months

First QC Date

June 18, 2024

Last Update Submit

June 28, 2024

Conditions

Exercise Induced CD8+ T Cell Recruitment and Characterization of Function and Phenotype of These Cells

Outcome Measures

Primary Outcomes (3)

  • CD8 T cell absolute nr after exercise

    CD8 nr

    Before, directly after, 60 minutes after exercise

  • CD8 T cell cytotoxicity against cancer cells

    CD8 T cell lysis of cancer cells

    Cryopreserved CD8 cells from Day 1 and Day 8 of the experiment, obtained before and after exercise

  • CD8 T cell pheontype after exercise

    Flow cytometry analysis of CD8 T cells

    Before, directly after, 30 minutes and 60 minutes after exercise

Study Arms (1)

Exercise

EXPERIMENTAL

Healthy human subjects performing 3 x 30 seconds of supramaximal exercise with blood obtained before and up to 60 minutes after the exercise bout

Procedure: Exercise

Interventions

ExercisePROCEDURE

3 x 30 seconds of supramaximal exercise

Exercise

Eligibility Criteria

Age20 Years - 36 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Be used to physical exercise and be able to perform strenous exercise Be able to attend the experimental procedure for the 90 minute duration of the study

You may not qualify if:

  • Smoking Pregnant Have any medical condition requiring medical treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karolinska Sjukhuset Huddinge

Huddinge, Stockholm County, Sweden

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Helene Rundqvist, PhD

    Karolinska Institutet

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD

Study Record Dates

First Submitted

June 18, 2024

First Posted

July 3, 2024

Study Start

March 31, 2023

Primary Completion

December 22, 2023

Study Completion

February 14, 2024

Last Updated

July 3, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing
Will not share

Locations

SE(1)