Use of Subanesthetic Dose Propofol Before Extubation

NCT07276633 | Completed DMC

• 1 other identifier: Subanesthetic Dose of Propofol
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

Conditions

Emergence Agitation; Rhinoplasty; Patient Satisfaction

Keywords

Propofol; Postoperative Recovery; Patient Satisfaction; Emergence Agitation; Rhinoplasty; General Anesthesia Recovery; Sub-Anesthetic Dose

Outcome Measures

Primary Outcomes (1)

• Changing Preoperative Anxiety Score (STAI)

  Comparison of the State-Trait Anxiety Inventory (STAI) state anxiety score measured in the preoperative waiting room (T1) with the STAI score 15 minutes after the palming technique (T2). The difference between the two time points is analyzed to assess the anxiety-reducing effect of the intervention.

  15 minutes (T1-T2)

Secondary Outcomes (2)

• Hemodynamic Parameter Changes

  15 minutes (T1-T2)

• Hemodynamic Parameter Changes

  15 minutes (T1-T2)

Study Arms (2)

Propofol Group

ACTIVE COMPARATOR

Sub-anesthetic dose of propofol (0.5 mg/kg) administered 10 minutes before extubation.

Other: Normal Saline (Placebo)

Control Group

SHAM COMPARATOR

Normal saline administered 10 minutes before extubation.

Drug: Propofol (Sub-Anesthetic Dose)

Interventions

Propofol (Sub-Anesthetic Dose) DRUG

Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation.

Also known as: Normal saline administered pre-extubation

Control Group

Normal Saline (Placebo) OTHER

Participants receive an equivalent volume of normal saline 10 minutes before extubation.

Propofol Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ages 18-65 years
• Patients scheduled for rhinoplasty surgery
• ASA physical status I-II
• No respiratory tract infection
• Provided written informed consent

You may not qualify if:

• Refusal to participate
• Presence of any respiratory tract infection
• Younger than 18 or older than 65
• ASA III-IV
• Known allergy to study medications
• Predicted difficult intubation

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Yuzuncu Yil University, Dursun Odabas Medical Center

Van, 65080, Turkey (Türkiye)

Location

Related Publications (1)

• Kanaya A, Kuratani N, Satoh D, Kurosawa S. Lower incidence of emergence agitation in children after propofol anesthesia compared with sevoflurane: a meta-analysis of randomized controlled trials. J Anesth. 2014 Feb;28(1):4-11. doi: 10.1007/s00540-013-1656-y. Epub 2013 Jun 26.

  PMID: 23800983 BACKGROUND

MeSH Terms

Conditions

Emergence Delirium; Patient Satisfaction

Interventions

Propofol; Saline Solution

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Treatment Adherence and Compliance; Health Behavior; Behavior

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Crystalloid Solutions; Isotonic Solutions; Solutions; Pharmaceutical Preparations

Study Officials

• Nureddin Yuzkat, Associate professor

  Yuzuncu Yil University Dursun Odabas Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: December 11, 2025
• Study Start: June 1, 2024
• Primary Completion: September 1, 2024
• Study Completion: October 1, 2024
• Last Updated: December 11, 2025

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)