Efficacy and Prognosis of Auxiliary Liver Transplantation

NCT07275008 | Not Yet Recruiting

• 1 other identifier: BFH20251127004
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this observational study is to systematically compare the efficacy and patient prognosis between auxiliary liver transplantation and living donor liver transplantation, and to explore the postoperative recovery, survival rate, rejection, postoperative complications, and long-term prognosis of patients undergoing auxiliary liver transplantation.

Conditions

Liver Transplantation; Auxiliary Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• Overall survival

  Within one year after liver transplantation

Secondary Outcomes (2)

• Complications

  Within one year after liver transplantation

• changes in peripheral blood lymphocytes

  within 3 months after liver transplantation

Study Arms (2)

auxiliary liver transplantation

Patients who underwent auxiliary liver transplantation at our center during the study period

living donor liver transplantation

Patients who underwent traditional orthotopic living donor liver transplantation at our center during the study period.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were treated at the Liver Transplantation Center of Beijing Friendship Hospital, Capital Medical University between December 2025 and December 2028, and who underwent either auxiliary liver transplantation (study group) or conventional liver transplantation (control group).

You may qualify if:

• Patients who underwent auxiliary liver transplantation or living donor liver transplantation (LDLT).
• Patients with complete medical records and follow-up data.

You may not qualify if:

• Patients who underwent retransplantation.
• Patients who underwent other organ transplantation (or multiorgan transplantation).
• Patients with severe missing postoperative follow-up data or loss to follow-up.

Sponsors & Collaborators

• Zhi-Jun Zhu: lead

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples were collected at 3 days, 7 days, 14 days, 1 month, and 3 months postoperatively for Olink proteomics analysis. Peripheral blood mononuclear cells (PBMCs) were isolated for flow cytometry detection.

Central Study Contacts

Bin Li

CONTACT

+8619935943688; libin_2024@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 27, 2025
• First Posted: December 10, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: December 10, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share