Effectiveness Analysis of a Rehabilitation Exercise Platform for Living Donor Liver Transplantation Patients

NCT07530913 | Enrolling By Invitation

• 1 other identifier: 2026-01-020
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled study aims to evaluate the effectiveness of a digital rehabilitation exercise platform in patients undergoing living donor liver transplantation. A total of 36 adult patients who require ongoing rehabilitation after living donor liver transplantation will be recruited and randomly assigned in a 1:1 ratio to either an intervention group or a control group. The intervention group will receive a personalized exercise program delivered through a digital rehabilitation platform in addition to standard exercise education, whereas the control group will receive standard exercise education only. Physical function, body composition, quality of life, and physical activity will be assessed before surgery, at discharge, at 1 month after discharge, and at 3 months after discharge to determine whether the digital rehabilitation platform improves recovery-related outcomes during the post-transplant period.

Conditions

Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• 6-Minute Walk Distance in meters

  Six-minute walk distance will be measured using the 6-Minute Walk Test to assess functional exercise capacity and physical endurance in patients undergoing living donor liver transplantation. The reported value will be the total distance walked in meters.

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge

Secondary Outcomes (7)

• Medical Research Council Sum Score

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge.

• Grip Strength in kilograms

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge.

• Short Physical Performance Battery total score

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge

• Functional Ambulation Categories score

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge.

• Skeletal Muscle Mass measured by bioelectrical impedance analysis

  Baseline (preoperative admission), on the day of hospital discharge from the index transplantation admission, 1 month after discharge, and 3 months after discharge.

Study Arms (2)

Digital Rehabilitation Platform Group

EXPERIMENTAL

Participants in this group will receive a personalized exercise program using a digital rehabilitation platform in addition to standard exercise education. During hospitalization, participants will perform platform-based exercise sessions with research staff, and after discharge they will continue self-exercise and self-management using the platform. Exercise content may be adjusted according to assessment results and participant condition.

Behavioral: Digital Rehabilitation Platform

Standard Exercise Education Group

ACTIVE COMPARATOR

Participants in this group will receive standard exercise education according to usual rehabilitation care procedures during hospitalization and will continue self-exercise and self-management after discharge based on the education and materials provided.

Behavioral: Standard Exercise Education

Interventions

Standard Exercise Education BEHAVIORAL

Usual rehabilitation exercise education provided during hospitalization for patients undergoing living donor liver transplantation, with instructions for continued self-exercise and self-management after discharge.

Standard Exercise Education Group

Digital Rehabilitation Platform BEHAVIORAL

A personalized digital rehabilitation exercise program for patients undergoing living donor liver transplantation. The program includes exercise guidance during hospitalization and continued home-based self-exercise and self-management after discharge through a digital rehabilitation platform.

Digital Rehabilitation Platform Group

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients undergoing living donor liver transplantation who require continuous rehabilitation treatment
• Adults aged 20 to 65 years
• Able to independently operate digital devices such as a smartphone or tablet PC
• Able to perform exercises and review feedback using the digital rehabilitation platform
• No significant impairment in hearing, vision, or cognitive function that would interfere with understanding audio and visual instructions provided by the platform

You may not qualify if:

• Patients with an inadequate level of consciousness or cognitive impairment making cooperation with the rehabilitation exercise program difficult
• Patients who have difficulty using digital devices or cannot independently use digital-based services
• Patients with severe limitations in muscle strength or range of motion, or amputation-related disability, making the exercise program difficult to perform
• Patients who require restriction of movement necessary for the rehabilitation exercise program due to fracture or musculoskeletal instability
• Patients with pain during upper or lower extremity movement and biomechanical instability that makes participation difficult
• Patients with visual or hearing impairment that interferes with cooperation in the rehabilitation exercise program
• Patients who develop medical complications or transplant rejection during study participation
• Patients unable to perform physical activity because of abdominal pain

Sponsors & Collaborators

• Samsung Medical Center: lead

Study Sites (1)

Samsung Medical Center

Seoul, South Korea

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 31, 2026
• First Posted: April 15, 2026
• Study Start: March 26, 2026
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)