Adrenaline V/s Dopamine in Fuid Refractory Septic Shock

NCT07273526 | Recruiting DMC

• 1 other identifier: #AVDSSC24#
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.

Conditions

Fluid Refractory Septic Shock; Septic Shock

Keywords

Septic Shock; Adrenaine; Dopamine; Fluid refractory septic shock

Outcome Measures

Primary Outcomes (5)

• Blood Pressure

  The blood pressure of the patients will be meaures after administration of each drug at 20 mins and 6 hours.

  6 hours

• Pulse

  The pulse will be compared after adminitration of both drugs at 20 mins and 6 hours

  6 hours

• Capillary Refill Time

  Capillary Refill time will be assessed after administration of each drug at 20 mins and 6 hours

  6 Hours

• Urine output

  Urine output will be calculated from the time of administration of each drug at 20mins and 6 hours and comapred.

  6 hours

• GCS

  Glascow Comma Scale (GCS) will be asses at 20 mins and 6 hours after administration of each drug

  6 hours

Secondary Outcomes (1)

• SOFA ( Sequential Organ Failure Assesment)

  6 Hours

Study Arms (2)

Group A

EXPERIMENTAL

These patients will receive 0.1-0.3ug/kg/min of adrenaline when diagnosed with fluid refractory Septic shock .

Drug: Adrenaline

Group B

ACTIVE COMPARATOR

The patients in this arm of study will be provided with dopamine 10-20ug/kg/min when diagnosed with fluid refractory septic shock.

Drug: Dopamine

Interventions

Adrenaline DRUG

The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock

Group A

Dopamine DRUG

The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.

Group B

Eligibility Criteria

• Age: 1 Month - 12 Months
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.

You may not qualify if:

• Patients with
• cardiopumonary Bypass during last 5 days
• Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
• neuromuscular discorder
• Metabolic disorders
• Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation

Sponsors & Collaborators

• Laiba Qamar: lead

Study Sites (1)

The Children Hospital and The Institute of Child Health Faisalabad

Faisalābad, Punjab Province, 38000, Pakistan

RECRUITING

MeSH Terms

Conditions

Shock, Septic

Interventions

Epinephrine; Dopamine

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Intervention Hierarchy (Ancestors)

Ethanolamines; Amino Alcohols; Alcohols; Organic Chemicals; Amines; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Central Study Contacts

Hafiz Muhammad Abdullah Dr, MBBS

CONTACT

03440846288; mbilal1857@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor Investigator

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 9, 2025
• Study Start: June 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: December 9, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)