Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome

NCT05134220 | Unknown

• 1 other identifier: Electrolytes
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.

Conditions

Acute Coronary Syndrome

Outcome Measures

Primary Outcomes (1)

• Chronic kidney disease hospitalization

  The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models.

  from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital

Study Arms (2)

Chronic Kidney Disease (CKD) patients with acute coronary syndrome

The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : 1. Electrocardiogram (ECG) changes: * ST elevation. * ST depression. * T wave inversion. * recent left bundle branch block. 2. Troponin elevation.

Diagnostic Test: Serum Calcium

Chronic Kidney Disease (CKD) patients without acute coronary syndrome

The CKD patient with or without dialysis with no previous history of ACS.

Diagnostic Test: Serum Calcium

Interventions

Serum Calcium DIAGNOSTIC_TEST

* Serum calcium level. * Serum phosphorus level. will be measured to all study population

Also known as: serum Phosphorus

Chronic Kidney Disease (CKD) patients with acute coronary syndrome; Chronic Kidney Disease (CKD) patients without acute coronary syndrome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

two groups : 1. CKD patients with and without dialysis who admitted to Sohag university hospital with acute coronary syndrome 2. CKD patients with and without dialysis who admitted to Sohag university hospital with no previous or current history of acute coronary syndrome

You may qualify if:

• The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features :
• a- Electrocardiogram (ECG) changes:
• ST elevation.
• ST depression.
• T wave inversion.
• recent left bundle branch block.
• b- Troponin T elevation.
• The CKD patient with or without dialysis with no previous history of ACS.

You may not qualify if:

• Patients who were diagnosed with primary hyperparathyroidism.
• Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012)
• Increase in S.Cr by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48hours; or
• Increase in S.Cr to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or
• Urine volume \<0.5 ml/kg/h for 6 hours

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university

Sohag, 82524, Egypt

RECRUITING

Related Publications (1)

• Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis. 1998 Apr;31(4):607-17. doi: 10.1053/ajkd.1998.v31.pm9531176.

  PMID: 9531176 BACKGROUND

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Central Study Contacts

Ahmed M YOUSEF, M.B.B.CH

CONTACT

01067439846; ahmed011032@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 6, 2021
• First Posted: November 24, 2021
• Study Start: November 30, 2021
• Primary Completion: May 30, 2022
• Study Completion: May 30, 2022
• Last Updated: November 24, 2021

Record last verified: 2021-11

Locations

EG (1)