Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief

NCT07267182 | Completed

• 1 other identifier: DR-SAIMA-QAMC
• Study Type: interventional
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Little is known about comparative efficacy of gabapentin and diclofenac sodium in managing post-operative pain. Therefore, this study was planned to compare the efficacy of gabapentin, and diclofenac sodium for post-operative pain relief in patients undergoing major abdominal surgeries.

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Pain reduction

  Patients were considered to have effective pain relief ("Yes") if their VAS score remained ≤3 throughout the monitoring period without requiring rescue analgesia.

  12 hours

Study Arms (2)

Gabapentin group

EXPERIMENTAL

Patients received a single oral dose of gabapentin 600 mg one hour before surgery.

Drug: Gabapentin 600mg

Diclofenac group

EXPERIMENTAL

Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.

Drug: Diclofenac Sodium 100 MG

Interventions

Gabapentin 600mg DRUG

Patients received a single oral dose of gabapentin 600 mg one hour before surgery.

Gabapentin group

Diclofenac Sodium 100 MG DRUG

Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.

Diclofenac group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Any gender
• Aged 18-60 years
• Undergoing elective major abdominal surgery under general anesthesia
• With physical status I or II
• Who were able to comprehend and use the Visual Analogue Scale (VAS) for pain assessment

You may not qualify if:

• With a known allergy or contraindication to gabapentin, or diclofenac sodium
• A history of peptic ulcer disease
• A history of gastrointestinal bleeding
• Hepatic or renal dysfunction
• Pregnancy or lactation
• With neurological or psychiatric disorders affecting pain perception
• Received opioids, anticonvulsants, antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours before surgery
• With uncontrolled hypertension, ischemic heart disease, or diabetes mellitus
• Those who experienced intraoperative complications necessitating a change in anesthetic plan or postoperative mechanical ventilation

Sponsors & Collaborators

• Muhammad Aamir Latif: lead

Study Sites (1)

Bahawal Victoria Hospital

Bahawalpur, Punjab Province, 63100, Pakistan

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Gabapentin; Diclofenac

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Amines; Organic Chemicals; gamma-Aminobutyric Acid; Aminobutyrates; Butyrates; Acids, Acyclic; Carboxylic Acids; Cyclohexanecarboxylic Acids; Acids, Carbocyclic; Cyclohexanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Amino Acids; Amino Acids, Peptides, and Proteins; Phenylacetates

Study Officials

• Saima Noreen

  Quid-e-Azam Medical College, Bahawalpur

  PRINCIPAL INVESTIGATOR

• Ambreen Khan

  Quid-e-Azam Medical College, Bahawalpur

  PRINCIPAL INVESTIGATOR

• Qazi Anees

  Quid-e-Azam Medical College, Bahawalpur

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Consultant

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: December 5, 2025
• Study Start: August 1, 2022
• Primary Completion: February 28, 2023
• Study Completion: February 28, 2023
• Last Updated: December 5, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)