Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease

NCT07260071 | Recruiting

• 1 other identifier: 347395
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed:

• Height and weight.
• Blood pressure.
• Non-invasive measurement of arterial stiffness.
• Cardiac and renal MRI.
• Blood sample.
• Genetic testing.

Conditions

Autosomal Dominant Polycystic Kidney Disease (ADPKD

Keywords

hypertension; children; young people; autosomal dominant polycystic kidney disease; arterial stiffness; genetic testing; albuminuria; proteinuria

Outcome Measures

Primary Outcomes (1)

• Number of participants with hypertension in general population of children and young people at risk of ADPKD.

  Diagnosis of hypertension from clinic manual blood pressure and 24 hours ambulatory blood pressure measurement

  Day 1

Secondary Outcomes (5)

• Number of participants diagnosed with ADPKD from renal MRI compared to the number from genetic testing.

  Day 1

• Number of participants with cyst negative but gene positive ADPKD in this age group.

  Day 1

• Number of participants with abnormal albuminuria in the population at risk of ADPKD.

  Single time point

• Central blood pressure in young people with ADPKD compared to healthy controls

  Day 1

• Arterial stiffness in young people with ADPKD compared to healthy controls

  Day 1

Study Arms (2)

ADPKD positive

Participants with positive renal MRI and/or genetic test for ADPKD

ADPKD negative

Participants with negative renal MRI and genetic test for ADPKD

Eligibility Criteria

• Age: 12 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

General population of children and young people at risk of ADPKD

You may qualify if:

• Age 12 - 17 years at the time of consent
• Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test)
• Parent with confirmed clinical diagnosis of ADPKD
• Parent (if child \<16 years) or both parent and young person (if \>=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this.

You may not qualify if:

• years or above at the time of study entry
• Unable to tolerate key study investigations
• Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations
• Unwilling to undergo genetic testing for ADPKD

Sponsors & Collaborators

• King's College London: lead
• Guy's and St Thomas' NHS Foundation Trust: collaborator

Study Sites (1)

Evelina London Children's Hospital

London, SE1 7EH, United Kingdom

RECRUITING

Related Publications (3)

• Ecder T, Schrier RW. Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease. Nat Rev Nephrol. 2009 Apr;5(4):221-8. doi: 10.1038/nrneph.2009.13.

  PMID: 19322187 BACKGROUND

• Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, Parfrey P, Cramer B, Coto E, Torra R, San Millan JL, Gibson R, Breuning M, Peters D, Ravine D. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol. 2009 Jan;20(1):205-12. doi: 10.1681/ASN.2008050507. Epub 2008 Oct 22.

  PMID: 18945943 BACKGROUND

• Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet. 2007 Apr 14;369(9569):1287-1301. doi: 10.1016/S0140-6736(07)60601-1.

  PMID: 17434405 BACKGROUND

Related Links

• Polycystic Kidney Disease Charity website

MeSH Terms

Conditions

Polycystic Kidney, Autosomal Dominant; Hypertension; Albuminuria; Proteinuria

Condition Hierarchy (Ancestors)

Polycystic Kidney Diseases; Kidney Diseases, Cystic; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Ciliopathies; Genetic Diseases, Inborn; Vascular Diseases; Cardiovascular Diseases; Urination Disorders; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Manish Sinha, PhD, MRCP (UK), MRCPCH

  King's College London

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Benjamin Boxer, PhD

CONTACT

+44 20 7188 4770; gstt.hiya.pkd@nhs.net

Louise Keehn, MSc

CONTACT

+44 20 7188 4770; louise.keehn@kcl.ac.uk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: December 2, 2025
• Study Start: August 15, 2025
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: December 2, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)