Adductor Canal Block With IPACK Versus Genicular Nerves Block With IPACK for Post-operative Analgesia

NCT07258277 | Not Yet Recruiting DMC

• 1 other identifier: 1391
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

In our study, we will find out the efficacy of those peripheral nerve blocks on postoperative pain in knee arthroscopy. The aim is to evaluate the efficacy of combined ultrasound-guided IPACK with adductor canal nerve block versus ultrasound-guided IPACK with genicular nerves block on postoperative pain in knee arthroscopy.

Conditions

Postoperative Analgesia

Keywords

IPACKL/ adductor canal block/ genicular nerves block

Outcome Measures

Primary Outcomes (1)

• first analgesic request

  the first time the patient will ask analgesia postoperative

  within 24 hours

Secondary Outcomes (3)

• Changes in Visual Analogue Score

  To be measured immediately postoperative, 2h later, 4h, 6h, 8h, 12h, 18h, 24h

• Total analgesic requirement

  within 24 hours

• Time Up and Go Test (TUG)

  postoperative: 6h, 12h, 18h and 24h.

Study Arms (3)

IA (IPACK with adductor cannal block)

ACTIVE COMPARATOR

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then another 15 ml of 0.25% plain bupivacaine at the mid-thigh for the ACB.

Other: IPACK with adductor canal block

IG (IPACK with genicular nerves block)

ACTIVE COMPARATOR

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then at the anterior surface of the knee 16 ml of 0.25% plain bupivacaine divided on the 4 genicular nerves (superior medial, superior lateral, inferior medial and inferior lateral).

Other: IPACK with Genicular nerves block

C (Spinal block)

ACTIVE COMPARATOR

won't receive any nerve block, only spinal anesthesia. \- Then spinal anesthesia will be given to all patients in the three groups, 3 ml (15 mg) 0.5% hyperbaric bupivacaine will be administered intrathecal at level of L3-4 or L4-5 interspace.

Other: Spinal Block

Interventions

IPACK with adductor canal block OTHER

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then another 15 ml of 0.25% plain bupivacaine at the mid-thigh for the ACB.

IA (IPACK with adductor cannal block)

IPACK with Genicular nerves block OTHER

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then at the anterior surface of the knee 16 ml of 0.25% plain bupivacaine divided on the 4 genicular nerves (superior medial, superior lateral, inferior medial and inferior lateral).

IG (IPACK with genicular nerves block)

Spinal Block OTHER

won't receive any nerve block, only spinal anesthesia. \- Then spinal anesthesia will be given to all patients in the three groups, 3 ml (15 mg) 0.5% hyperbaric bupivacaine will be administered intrathecal at level of L3-4 or L4-5 interspace.

C (Spinal block)

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA l \& ll
• planned to undergo elective unilateral knee surgeries under spinal anesthesia
• age between 20 to 70 years old
• both sex

You may not qualify if:

• Patient refusal
• Neurological deficiencies prior to surgery
• Severe Cardiovascular, renal and hepatic comorbidities
• Hematological disorders and abnormal coagulation parameters
• Psychiatric illnesses and opioid addiction
• Allergies to any of the medications will be utilized in the study

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Minia University Hospital

Minya, Minya Governorate, Egypt

Location

MeSH Terms

Interventions

Anesthesia, Spinal

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Study Officials

• Gehad Fathy Sadek, MD

  Minia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gehad F Sadek, MD of anesthesiology and ICU

CONTACT

0862344787; gehad.fathy@minia.edu.eg

Abdelrahman Seif Amih, MBBCH

CONTACT

abdelrahmansaif480@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology and ICU

Model Details: This prospective randomized controlled clinical study will be conducted in anesthesiology and intensive care department at Minia University Hospital (MUH) on 72 adult patients of both genders, aged between 20 years to 70 years old, ǀ and ǀǀ classification of The American Society of Anesthesiologists (ASA) planned to undergo elective unilateral knee surgeries under spinal anesthesia.Our 72 patients were randomly divided into 3 groups, each group includes 24 patients

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: December 2, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): February 1, 2027
• Last Updated: December 2, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)