NCT07254624

Brief Summary

The purpose of this study is to determine whether continuous glucose monitoring is sensitive to quantifying the glucose response related to consumption of a starchy vegetable (potato) in combination with or separate from consumption of herbs and spices at the same meal.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
18mo left

Started Mar 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress9%
Mar 2026Nov 2027

First Submitted

Initial submission to the registry

November 19, 2025

Completed
9 days until next milestone

First Posted

Study publicly available on registry

November 28, 2025

Completed
4 months until next milestone

Study Start

First participant enrolled

March 16, 2026

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2026

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2027

Last Updated

March 20, 2026

Status Verified

March 1, 2026

Enrollment Period

8 months

First QC Date

November 19, 2025

Last Update Submit

March 19, 2026

Conditions

Post-prandial Glucose Response

Keywords

post-meal glucose response

Outcome Measures

Primary Outcomes (1)

  • Post-prandial glucose response

    Glucose response will be measured using continuous glucose monitors. These devices will capture changes in glucose response from the start of the meal to about 2 hours postprandial.

    0, 1, and 2 hours post-meal, as well as 24 hour continuous

Secondary Outcomes (1)

  • Acceptance assessment

    0-10 days

Study Arms (3)

Potato entree with no herbs or spices

SHAM COMPARATOR

consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms

Other: Potato entree

Potato entree with herbs or spices

EXPERIMENTAL

consumption of a standardized potato entree including a mix of five herbs and spices at a fixed amount, matched for macronutrient, calorie and preparation method across arms

Other: Mix of five herbs and spicesOther: Potato entree

Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal

SHAM COMPARATOR

consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms - with a provision including a mix of five herbs and spices at a fixed amount to be consumed at a subsequent meal within the same day (\>2 hours following the potato entree consumption)

Other: Mix of five herbs and spicesOther: Potato entree

Interventions

Mix of five herbs and spicesOTHER

Herb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder

Potato entree with herbs or spicesPotato entree with no herbs or spices, with herbs and spices mix at a subsequent meal
Potato entreeOTHER

A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response

Potato entree with herbs or spicesPotato entree with no herbs or spicesPotato entree with no herbs or spices, with herbs and spices mix at a subsequent meal

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • body mass index (BMI): 20-35
  • no dietary restriction or food allergies to study items
  • weight stable
  • access to a smart phone
  • willingness to wear a continuous glucose monitor for the duration of the study (at minimum 10 days)

You may not qualify if:

  • pregnancy or anticipating pregnancy or lactation
  • food allergy to study items
  • diagnosed diabetes (type 1 or 2) or taking diabetes medications
  • history of bariatric surgery
  • consumed \>1 serving of potatoes daily before enrollment
  • % weight loss or gain within the past 6 months
  • medical conditions or medication that would prevent the ability to comply with the treatment assignment and/or affect blood glucose or energy balance
  • condition which would prevent the ability to wear a continuous glucose monitor on the upper arm for the study duration

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

RECRUITING

MeSH Terms

Interventions

Spices

Intervention Hierarchy (Ancestors)

CondimentsFoodDiet, Food, and NutritionPhysiological PhenomenaFood and Beverages

Central Study Contacts

Daniel L Smith Jr, PhD

CONTACT

205-934-4086dsmithjr@uab.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
CROSSOVER
Model Details: Participants will serve as their own controls in this study. They will be randomized to the order they receive the prepared entrees. Post-prandial glucose responses will be compared across the three entree types.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

November 19, 2025

First Posted

November 28, 2025

Study Start

March 16, 2026

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

November 1, 2027

Last Updated

March 20, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Individual de-identified participant data will be shared or made publicly available for any publication of findings.

Time Frame
Following publication of results
Access Criteria
Public repository

Locations

US(1)