Role of SPECT/CT of Bone Scan in Charactarization of Bone Lesions

NCT07248033 | Not Yet Recruiting

• 1 other identifier: SPECT/CT in bone scan
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational study aims to assess the diagnostic value of SPECT/CT of 99mTc-MDP bone scintigraphy in differentiating begnin from malignant bone lesions. The main question it aims to answer is: ●Can SPECT/CT-derived quantitative parameters (SUVmax, SUVmean) accurately differentiate between begnin and malignant bone lesions in clinical settings? Final diagnostic impression: confirmed by biopsy (if available), or through multidisciplinary radiologic-clinical correlation

Conditions

Bone Lesions

Outcome Measures

Primary Outcomes (2)

• To measure SUVmax and SUVmean of bone lesions using quantitative SPECT/CT.

  Baseline

• To compare these values between malignant and degenerative lesions confirmed by clinical, histological, or radiological follow-up.

  Baseline

Secondary Outcomes (1)

• To establish a diagnostic SUV cut-off value that aids in distinguishing between lesion types.

  Baseline

Interventions

SPECT/CT DEVICE

It is a medical imaging test that combines a Single-Photon Emission Computed Tomography (SPECT) scan with a Computed Tomography (CT) scan to provide both detailed physiological (function) and anatomical (structure) information about the body. A radioactive tracer is injected and detected by the SPECT camera to show organ function, while the CT scan captures precise images of the body's structures, allowing for precise localization of the tracer and identification of abnormalities in a single, comprehensive study.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of patients referred to the Nuclear Medicine Unit at Assiut University, for bone imaging using 99mTc-MDP SPECT/CT due to clinical suspicion of bone lesions.

You may qualify if:

• Any age referred for 99mTc-MDP SPECT/CT
• Clinical suspicion of either metastatic or degenerative etiology

You may not qualify if:

• Case with double malignancies
• Pregnant patients
• Severely ill patients

Sponsors & Collaborators

• MennaTalla Saber Sabet Mohamed: lead

MeSH Terms

Interventions

Single Photon Emission Computed Tomography Computed Tomography

Intervention Hierarchy (Ancestors)

Tomography, Emission-Computed, Single-Photon; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Central Study Contacts

MennaTalla Saber Sabet

CONTACT

01151322001; Sebastian.kuroshitsuji1@gmail.com

Walaa Oteify, Lecturer

CONTACT

01029304463; walaa@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: November 25, 2025
• Study Start: November 1, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 25, 2025

Record last verified: 2025-10