The Role of Tc 99m MDP SPECT/CT in Osteoarthritis

NCT03290807 | Unknown

• 1 other identifier: SPECT/CT in osteoarthritis
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Evaluation of the diagnostic value of SPECT/CT in patients with knee and/or hip OA, whether it is related to clinical findings and it could reflect clinical disease activity, and to determine the usefulness of SPECT/CT in early detection of OA.

Conditions

Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Detecting different pattern of osseous MDP uptake in patient with osteoarthritis in hip joints and/or knees in relation to clinical and simple radiographic findings.

  Osteoarthritic patients will be examined with 99mTc-methylene diphosphonate (MDP) bone SPECT, the sites of uptake will be localized. Simple radiograph and physical examination will be assessed.The relationships between clinical findings, simple radiographic findings and the intensity of uptake in SPECT will be analyzed.

  Baseline

Interventions

SPECT/CT DEVICE

Combined single photon emission computerized tomography and conventional computerized tomography (SPECT/CT) is a hybrid imaging modality, which combines a 3D bone scintigraphy (SPECT) and a conventional CT into one imaging procedure. The use of SPECT/CT offers the benefit of combined anatomical, mechanical (CT) and functional imaging (SPECT)

Eligibility Criteria

• Age: 30 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Adult patient above 30 years old. * Clinically diagnosed osteoarthritis before treatment. * Patient with refractory active osteoarthritis (not responding to treatment). * Ability to sleep in fixed position for about 25 minutes * Ability to provide informed consent.

You may qualify if:

• Adult patient above 30 years old.
• Clinically diagnosed osteoarthritis before treatment.
• Patient with refractory active osteoarthritis (not responding to treatment).
• Ability to sleep in fixed position for about 25 minutes
• Ability to provide informed consent.

You may not qualify if:

• Patient with resolved osteoarthritis.
• patient with other disease in joints:
• Avascular necrosis
• Stress fracture
• Neuropathic pain

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Osteoarthritis

Interventions

Single Photon Emission Computed Tomography Computed Tomography

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Tomography, Emission-Computed, Single-Photon; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Central Study Contacts

Fatma- Elzahraa Mostafa mahmoud

CONTACT

01095529911; fatma.mostafa07@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident physicians

Study Record Dates

• First Submitted: September 18, 2017
• First Posted: September 25, 2017
• Study Start: October 1, 2017
• Primary Completion: October 1, 2019
• Study Completion: November 1, 2019
• Last Updated: September 25, 2017

Record last verified: 2017-09