Enhanced Recovery After Uvulopalatoplasty

NCT07246694 | Active Not Recruiting

• 1 other identifier: Uvulopalatoplasty Analgesia
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive sleep apnea is a prevalent condition often treated surgically with palatoplasty, which improves airway patency and reduces apneic events. However, postoperative pain and airway discomfort following palatoplasty can be significant, leading to delayed oral intake, increased opioid consumption, and prolonged recovery. Combining an ultrasound-guided glossopharyngeal nerve block with topical airway anesthesia may provide synergistic analgesia and support a safer recovery profile.

Conditions

Analgesia; Recovery, Psychological

Outcome Measures

Primary Outcomes (1)

• The recovery time

  The time from from inhalational anesthetic discontinuation to the first response to verbal command.

  1 hour

Secondary Outcomes (5)

• Additional intraoperative analgesia

  4 hours

• Postoperative pain assessment

  The first 24 hours postoperative.

• Total rescue analgesia

  The first 24 hours postoperative.

• Incidence of complications

  4 hours

• Quality of recovery

  The first 24 hours postoperative.

Study Arms (2)

Group I

ACTIVE COMPARATOR

The patient will receive the ultrasound-guided glossopharyngeal nerve block combined with topical airway anesthesia.

Procedure: Glossopharyngeal nerve block

Group c

ACTIVE COMPARATOR

The patient will receive the standard multimodal analgesia.

Other: Standard multimodal analgesia

Interventions

Standard multimodal analgesia OTHER

The patient will receive intravenous fentanyl and non opioids analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) with general anesthesia.

Group c

Glossopharyngeal nerve block PROCEDURE

Glossopharyngeal nerve block using ultrasound guidance after induction of general anesthesia plus topical anesthesia before surgical incision.

Group I

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Confirmed diagnosis of moderate to severe obstructive sleep apnea.
• Patients scheduled for elective palatoplasty under general anesthesia.
• American Society of Anesthesiologists Physical Status class I and II.

You may not qualify if:

• Patients with chronic opioid use.
• Advanced hepatic, renal, cardiovascular, and neurologic diseases.

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Zagazig university hospital

Zagazig, Al-Sharkia, 44519, Egypt

Location

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Fatma Mahmoud Ahmed, MD

  Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

  PRINCIPAL INVESTIGATOR

• Alshaimaa Abdelfattah Kamel, MD

  Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

  STUDY DIRECTOR

• Osama Yehia Khalifa, MD

  Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 24, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: May 6, 2026

Record last verified: 2025-11

Locations

EG (1)