Compare Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided ACB for Postoperative Analgesia After Knee Surgeries
Comparative Study of Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-Guided Adductor Canal Block for Postoperative Analgesia After Knee Surgeries
1 other identifier
interventional
15
0 countries
N/A
Brief Summary
This study aims to compare morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided ACB for postoperative analgesia after knee surgeries
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_1
Started Nov 2025
Shorter than P25 for phase_1
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 16, 2025
CompletedStudy Start
First participant enrolled
November 17, 2025
CompletedFirst Posted
Study publicly available on registry
November 20, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2026
CompletedNovember 20, 2025
November 1, 2025
2 months
November 16, 2025
November 16, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Primary outcome:
• Time to first rescue analgesia .
24 hours postoperatively.
Study Arms (3)
Group D
EXPERIMENTALPatients will receive ACB using 20 ml of bupivacaine 0.25%+ 0.5 µg/kg dexmedetomidine.
Group M
EXPERIMENTALPatients will receive ACB using 20 ml of bupivacaine 0.25% +0.1 mg/kg morphine.
Group C
EXPERIMENTALPatients will receive ACB using 20 ml of bupivacaine 0.25% alone as a control group.
Interventions
This study aims to compare morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided ACB for postoperative analgesia after knee surgeries. Primary outcome: • Time to first rescue analgesia . Secondary outcomes: * Total opioid consumption in 24 hours postoperatively. * Degree of pain using visual analogue scale (VAS). * Degree of patient satisfaction. * Incidence of complication A) Related to block Nerve Injury Vascular Puncture Hematoma B) Related to drug Local Anesthetic Systemic Toxicity (LAST)
Eligibility Criteria
You may qualify if:
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I-II.
- Body mass index (BMI) of 20-35 kg/m2.
- Undergoing knee surgeries under spinal anesthesia.
You may not qualify if:
- Any known allergy or contraindication to local anesthetic.
- History of substance abuse.
- Decompansated cardiac, pulmonary, hepatic, renal disease.
- Obese patients with BMI\>35kg/m2.
- Pregnant and lactating mothers.
- Coagulopathies.
- Local skin infections at the site of injection.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Ashraf Abd El-Nasser Abd El-Hamid kamel El Rewany Anesthesia KafrElsheikh University Faculty of Medicine Anesthesia, Surg, MBBCH
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Ashraf Elrewany
Study Record Dates
First Submitted
November 16, 2025
First Posted
November 20, 2025
Study Start
November 17, 2025
Primary Completion
January 1, 2026
Study Completion
February 1, 2026
Last Updated
November 20, 2025
Record last verified: 2025-11
Data Sharing
- IPD Sharing
- Will not share