A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.

NCT07234331 | Recruiting

• 1 other identifier: RC24_0586
• Study Type: observational
• Target: 1,600
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to model the relationship between the prevalence of ESBL-E and CPE carriage among nursing home residents and their respective concentrations in wastewater discharged from the facility.

Conditions

Antimicrobial Resistance

Keywords

Nursing home; Wastewater; Surveillance

Outcome Measures

Primary Outcomes (1)

• Predictive performance

  The primary endpoint will be the adequacy and predictive performance of the model for estimating the prevalence of ESBL-E/CPE carriage among nursing home residents. Carriage prevalence will be measured by collecting stool samples from residents or, failing that, by anorectal swabs.

  15 months

Secondary Outcomes (1)

• Epidemiology of ESBL/CPE in nursing homes

  15 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Nursing home residents located in Loire-Atlantique and Maine-et-Loire, France

You may qualify if:

• Residents present on the day of sampling (D0 or D+1) in a facility selected during randomization, without criteria regarding length of stay in the facility, and whose health status on the day of the survey permits it;
• Residents who, based on clinical criteria (including an MMSE greater than or equal to 20), are deemed by the nursing home team to be able to understand the issues of the study and to express an informed non-opposition; OR Residents who the nursing home team considers unable to express an informed non-objection but who have a legal representative, a trusted person, or a loved one capable of understanding the information and expressing an informed non-objection.
• Residents may be included regardless of the presence of infection, diarrheal stools, antibiotic use or any other treatment, or health status.
• Participants in this study may participate in other research projects concurrently.

You may not qualify if:

• Residents whose health status is incompatible with performing the procedure on the day of the survey (e.g., end-of-life with comfort care);
• Residents with a Mini Mental State Examination (MMSE) score of less than or equal to 20, or without an MMSE score but who, according to nursing home professionals, are unable to provide an informed non-objection and who do not have a legal representative, trusted person, or relative capable of receiving information and providing an informed non-objection;
• Residents, regardless of their MMSE score, who refuse to have the sample taken on the day of the survey even if their legal repre

Sponsors & Collaborators

• Nantes University Hospital: lead

Study Sites (2)

CHU d'Angers

Angers, 49100, France

RECRUITING

CHU de Nantes

Nantes, 44093, France

RECRUITING

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 18, 2025
• Study Start: March 16, 2026
• Primary Completion (Estimated): March 31, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: April 16, 2026

Record last verified: 2025-11

Locations

FR (2)