Efficacy and Cost-effectiveness of Hospital Antimicrobial Stewardship Programs

NCT02814877 | Completed

• 1 other identifier: PHRQ15622
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of the project is to evaluate the efficiency and cost-effectiveness of different strategies aiming at optimizing antibiotic prescribing in hospitals. In the first section of the project, the project team intend to map the different antimicrobial stewardship programs in French hospital, by investigating a sample of 30 healthcare facilities, and determine the strategies to be evaluated by the model. The investigators will also evaluate physicians' adherence to the intervention to promote better use of antibiotics and explore potential barriers and facilitators to the implementation of effective strategies.

Conditions

Antimicrobial Resistance

Keywords

Antibiotic stewardship; cost-effectiveness evaluation; Antibiotic use

Outcome Measures

Primary Outcomes (1)

• Evaluate the efficacy and the cost-effectiveness of strategies to promote appropriate use of antibiotics in hospitals and identify the most efficient ones, on a short-term but also long-term scale.

  A comparison of the different strategies based on the incremental cost-effectiveness ratio (ICER), which is defined by the difference in costs between interventions, divided by the difference in their measured impact

  12 months

Secondary Outcomes (3)

• to map the different antimicrobial stewardship setups in french hospital

  12 months

• to measure prescribers' adherence to the different strategies used to control antibiotic description

  12 months

• to identify potential barriers and facilitators to the implementation of effective stewardship programs

  12 months

Interventions

promotion of appropriate use of antibiotics in hospital OTHER

promotion of appropriate use of antibiotics in hospital by visiting physicians

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

healthcare facilities

You may qualify if:

• French hospitals (acute care) selected

You may not qualify if:

• None

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Perozziello

Paris, France

Location

Related Publications (2)

• Perozziello A, Routelous C, Charani E, Truel A, Birgand G, Yazdanpanah Y, Lescure FX, Lucet JC; CEFECA Study Group. Experiences and perspectives of implementing antimicrobial stewardship in five French hospitals: a qualitative study. Int J Antimicrob Agents. 2018 Jun;51(6):829-835. doi: 10.1016/j.ijantimicag.2018.01.002. Epub 2018 Jan 12.

  PMID: 29339297 RESULT

• Perozziello A, Lescure FX, Truel A, Routelous C, Vaillant L, Yazdanpanah Y, Lucet JC; CEFECA study group. Prescribers' experience and opinions on antimicrobial stewardship programmes in hospitals: a French nationwide survey. J Antimicrob Chemother. 2019 Aug 1;74(8):2451-2458. doi: 10.1093/jac/dkz179.

  PMID: 31167027 RESULT

MeSH Terms

Interventions

Hospitals

Intervention Hierarchy (Ancestors)

Health Facilities; Health Care Facilities Workforce and Services

Study Officials

• Jean Christophe LUCET

  APHP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2016
• First Posted: June 28, 2016
• Study Start: September 1, 2016
• Primary Completion: September 1, 2017
• Study Completion: December 31, 2017
• Last Updated: November 24, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)