Resistance Profile of Escherichia Coli in Infections of Community Origin: The Importance of Antimicrobial Stewardship

NCT06305455 | Not Yet Recruiting

• 1 other identifier: HSD135
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The main objective of the study is to describe the antimicrobial resistance profile of E. coli isolated in patients from the community - defined as those with cultures collected within 48 hours of hospital admission - and admitted to the intensive care unit.

Conditions

Antimicrobial Resistance

Keywords

antimicrobial resistance; Escherichia coli ESBL; antimicrobial stewardship; community infections

Outcome Measures

Primary Outcomes (1)

• Prevalence of Escherichia coli resistance

  The main objective of the study is to describe the antimicrobial resistance profile of E. coli isolated in patients from the community admitted to the ICU.

  24 months

Interventions

Escherichia coli ESBL BIOLOGICAL

To evaluate the change in the resistance profile of infections of community origin caused by Escherichia coli, isolated from any culture material in patients admitted to the intensive care unit of a tertiary hospital.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients with severe Escherichia coli infections, isolated from any culture material collected within less than 48 hours of hospital admission, admitted to the intensive care unit of a tertiary hospital.

You may qualify if:

• All 18 years and old patients admitted to the ICU
• Positive cultures for E. coli
• Any sample collected within 48 hours of hospital admission

You may not qualify if:

• Lack of necessary data

Sponsors & Collaborators

• José Raimundo Araujo de Azevedo: lead

Related Publications (5)

• Eisenreich W, Rudel T, Heesemann J, Goebel W. Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens. Front Cell Infect Microbiol. 2022 Jul 19;12:900848. doi: 10.3389/fcimb.2022.900848. eCollection 2022.

  PMID: 35928205 RESULT

• Zhu DM, Li QH, Shen Y, Zhang Q. Risk factors for quinolone-resistant Escherichia coli infection: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2020 Jan 9;9(1):11. doi: 10.1186/s13756-019-0675-3. eCollection 2020.

  PMID: 31938541 RESULT

• Castanheira M, Deshpande LM, Mendes RE, Canton R, Sader HS, Jones RN. Variations in the Occurrence of Resistance Phenotypes and Carbapenemase Genes Among Enterobacteriaceae Isolates in 20 Years of the SENTRY Antimicrobial Surveillance Program. Open Forum Infect Dis. 2019 Mar 15;6(Suppl 1):S23-S33. doi: 10.1093/ofid/ofy347. eCollection 2019 Mar.

  PMID: 30895212 RESULT

• Canton R, Gijon D, Ruiz-Garbajosa P. Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic. Curr Opin Crit Care. 2020 Oct;26(5):433-441. doi: 10.1097/MCC.0000000000000755.

  PMID: 32739970 RESULT

• Kim JY, Yum Y, Joo HJ, An H, Yoon YK, Kim JH, Sohn JW. Impact of antibiotic usage on extended-spectrum beta-lactamase producing Escherichia coli prevalence. Sci Rep. 2021 Jun 22;11(1):13024. doi: 10.1038/s41598-021-91332-x.

  PMID: 34158540 RESULT

Study Officials

• RODRIGO AZEVEDO, MD, PhD

  Hospital São Domingos

  STUDY DIRECTOR

Central Study Contacts

RODRIGO AZEVEDO, MD, PhD

CONTACT

+55 98 991920321; rpdeazevedo@gmail.com

VITORIA OLIVEIRA, MD

CONTACT

+55 98 32168110; vitoriagoncaalves@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Clinical Researcher

Study Record Dates

• First Submitted: March 5, 2024
• First Posted: March 12, 2024
• Study Start: April 1, 2024
• Primary Completion: July 1, 2024
• Study Completion: October 1, 2024
• Last Updated: March 12, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share